Dám A M, Gazsó L G, Bodó K
Frederic Joliot-Curie National Research Institute for Radiobiology and Radio-Hygiene, Budapest, Hungary.
Acta Oncol. 1990;29(8):1055-8. doi: 10.3109/02841869009091799.
It has been reported that the aminothiol compound WR-2721 is a promising radioprotective agent and in combination with misonidazole (MISO) seems to be of therapeutic benefit. Since the radiomodification is oxygen-dependent, the actual oxygen status of cells and the surrounding media is an important factor influencing their effectiveness. Escherichia coli B/r radioresponse was studied either alone or in combination with these compounds at various oxygen concentrations ranging from anoxia to high oxygen content. WR-2721 had a protective effect under anoxic conditions and gave overall protection when oxygen was present. The maximum protection was seen at 3.2% O2 in N2 (PF 2.08). In combination with MISO the hypoxic sensitization of MISO was completely abolished by WR-2721, resulting in radioprotection under hypoxic conditions as well. Under euoxic conditions MISO was able to reduce the protective effect of WR-2721 by about 21%. According to our results MISO and WR-2721 influence each other in their radiomodifying effect in either fixation or repair of the radiation-induced damage.
据报道，氨基硫醇化合物WR-2721是一种很有前景的辐射防护剂，与米索硝唑（MISO）联合使用似乎具有治疗益处。由于辐射修饰作用依赖于氧，细胞及周围介质的实际氧状态是影响其有效性的一个重要因素。研究了大肠杆菌B/r在从无氧到高氧含量的各种氧浓度下单独或与这些化合物联合使用时的辐射反应。WR-2721在无氧条件下具有保护作用，在有氧气存在时能提供全面保护。在氮气中氧气含量为3.2%时观察到最大保护作用（防护因子为2.08）。与MISO联合使用时，WR-2721完全消除了MISO的低氧增敏作用，在低氧条件下也产生了辐射防护效果。在常氧条件下，MISO能够使WR-2721的保护作用降低约21%。根据我们的结果，MISO和WR-2721在辐射诱导损伤的固定或修复过程中，在其辐射修饰作用方面相互影响。
