Department of Psychopharmacology, National Institute of Mental Health & Neurosciences, Bangalore -560 029.
Indian J Psychiatry. 1992 Apr;34(2):128-32.
Plasma homovanillic acid (pHVA) levels were estimated in 20 cases of schizophreniform disorder, 14 cases of schizophrenia 'on medication' and 17 cases of schizophrenia 'off medication'. A bimodal distribution of pHVA was seen in schizophreniform disorder subjects, suggesting heterogenous groups in terms of dopaminergic function. No significant difference in the pHVA values was seen in the 3 groups, nor was there a relationship between the severity of the illness and the pHVA values; these results suggest plasticity of the dopaminergic system to neuroleptics.
对 20 例精神分裂样障碍患者、14 例“用药”精神分裂症患者和 17 例“停药”精神分裂症患者的血浆高香草酸（pHVA）水平进行了评估。精神分裂样障碍患者的 pHVA 呈双峰分布，提示多巴胺能功能存在异质性群体。3 组间 pHVA 值无显著差异，病情严重程度与 pHVA 值之间也无关系；这些结果提示多巴胺能系统对神经阻滞剂具有可塑性。
