Chang W H, Chen T Y, Lee C F, Hung J C, Hu W H, Yeh E K
Department of Adult Psychiatry, Taipei City Psychiatric Center, Taiwan, ROC.
Psychiatry Res. 1988 Mar;23(3):239-44. doi: 10.1016/0165-1781(88)90014-5.
Plasma levels of homovanillic acid (HVA), a major metabolite of dopamine, were measured in a group of 24 schizophrenic inpatients before and during 6 weeks of haloperidol (HAL) treatment. Steady-state plasma HAL levels were measured in parallel with plasma HVA. Differential plasma HVA responses to HAL treatment were found between good and poor outcome patients. The two groups did not differ significantly in plasma HAL levels. Two hypothetical subtypes of schizophrenia are proposed.
对一组24名精神分裂症住院患者在服用氟哌啶醇（HAL）治疗前及治疗6周期间，测定了多巴胺的主要代谢产物高香草酸（HVA）的血浆水平。同时测定了血浆HAL的稳态水平与血浆HVA水平。结果发现，疗效好与疗效差的患者对HAL治疗的血浆HVA反应存在差异。两组患者的血浆HAL水平无显著差异。据此提出了精神分裂症的两种假设亚型。
