通过酸介导环化构建2-硫尿嘧啶环实现GPR40拮抗剂的可行性合成
Feasible Synthesis of Antagonist of GPR40 by Constructing 2-Thiouracil Ring viaAcid Mediated Cyclization.
作者信息
Zhao Yongfeng, Song Yang, Shen Xiulin, Liao Jiayu
机构信息
Department of Bioengineering, Bourns College of Engineering, University of California-Riverside, Riverside, CA 92507, USA.
出版信息
Heterocycles. 2011 May 1;83(5):1145-1151. doi: 10.3987/COM-11-12175.
Abstract
GW1100 is an antagonist of GPR40 identified by high throughput screening recently. The synthesis of GW1100 has been developed. The key step involves cyclization of the 2-thiouracil heterocycle under acidic condition at room temperature.
摘要
GW1100是最近通过高通量筛选鉴定出的GPR40拮抗剂。GW1100的合成方法已经开发出来。关键步骤包括在室温酸性条件下2-硫脲杂环的环化反应。
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