Kofink Christiane C, Knochel Paul
Department Chemie und Biochemie, Ludwig-Maximilians-Universität, Butenandtstrasse 5-13, 81377 Munich, Germany.
Org Lett. 2006 Aug 31;8(18):4121-4. doi: 10.1021/ol0616790.
A combination of copper chloride, triethyl phosphite, and tetrabutylammonium iodide is a very efficient catalytic system for the synthesis of polyfunctionalized diarylmethanes, using the cross-coupling reaction of arylmagnesium halides with benzylic phosphates. The antibiotic Trimethoprim has been prepared using this Cu(I)-catalyzed cross-coupling in 52% overall yield (four steps).
氯化铜、亚磷酸三乙酯和碘化四丁基铵的组合是一种非常有效的催化体系，用于合成多官能化二芳基甲烷，该反应利用芳基卤化镁与苄基磷酸酯的交叉偶联反应。抗生素甲氧苄啶已使用这种铜（I）催化的交叉偶联反应制备，总产率为52%（四步）。
