Iftinca M C
Foothills Medical Centre, Department of Pathology, Calgary, AB, T2N 2T9, Canada.
J Med Life. 2011 May 15;4(2):126-38. Epub 2011 May 25.
This review summarizes recent advances in our understanding of neuronal T-type calcium channel regulation as well as their physiological and pathophysiological roles. Through their ability to conduct calcium across the cellular membrane at potentials close to the resting potential, T-type calcium channels are critically important for regulating neuronal excitability, both in the central and peripheral nervous system. T-type channels are also linked to an increasing number of neurological disorders such as the absence epilepsy and neuropathic pain. Although there is substantial literature dealing with regulation of native T-type channels, the underlying molecular mechanism has only recently been addressed. It is, therefore, critical to understand the cellular mechanisms that control T-type channel activity and expression, because this could provide important insight into designing novel therapeutic strategies targeting these channels.
本综述总结了我们对神经元T型钙通道调节及其生理和病理生理作用的最新认识进展。T型钙通道能够在接近静息电位的电位下跨细胞膜传导钙，对于调节中枢和外周神经系统的神经元兴奋性至关重要。T型通道还与越来越多的神经系统疾病有关，如失神癫痫和神经性疼痛。尽管有大量文献涉及天然T型通道的调节，但潜在的分子机制直到最近才得到研究。因此，了解控制T型通道活性和表达的细胞机制至关重要，因为这可为设计针对这些通道的新型治疗策略提供重要见解。
