Taubman Michele L, Goldfarb Melanie, Lew John I
Division of Endocrine Surgery, DeWitt Daughtry Family Department of Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136, USA.
Int J Mol Imaging. 2011;2011:141593. doi: 10.1155/2011/141593. Epub 2011 Jun 21.
Primary hyperparathyroidism is the most common cause of hypercalcemia in the outpatient population. This condition is usually the result of a single hyperfunctioning parathyroid gland. Targeted parathyroidectomy guided by intraoperative parathyroid hormone monitoring (IPM) through a small cervical incision has replaced traditional bilateral neck exploration (BNE) as the initial approach in the surgical treatment of primary hyperparathyroidism at many medical centers worldwide. Preoperative sestamibi-technetium 99m scintigraphy serves as an important prerequisite for successful targeted parathyroidectomy. Single-photon emission computed tomography (SPECT) and CT fusion, however, is a recent imaging technique that provides a three-dimensional functional image with advanced contrast resolution to greatly improve preoperative localization of parathyroid tumors.
原发性甲状旁腺功能亢进是门诊患者高钙血症最常见的病因。这种情况通常是由单个甲状旁腺功能亢进引起的。在全球许多医疗中心，通过颈部小切口在术中甲状旁腺激素监测（IPM）引导下进行的靶向甲状旁腺切除术已取代传统的双侧颈部探查（BNE），成为原发性甲状旁腺功能亢进外科治疗的初始方法。术前99m锝-甲氧基异丁基异腈闪烁扫描是成功进行靶向甲状旁腺切除术的重要前提。然而，单光子发射计算机断层扫描（SPECT）与CT融合是一种最新的成像技术，它能提供具有高对比度分辨率的三维功能图像，极大地提高甲状旁腺肿瘤的术前定位。
