Lukeis R, Irving L, Garson M, Hasthorpe S
Cytogenetics Department, St. Vincent's Hospital, Melbourne, Australia.
Genes Chromosomes Cancer. 1990 Jul;2(2):116-24. doi: 10.1002/gcc.2870020207.
Cytogenetic analysis of ten primary non-small cell lung carcinomas (NSCLC), including five adenocarcinomas (ADC), three squamous cell (SQC), and two large cell (LCC) carcinomas has been carried out in an attempt to determine karyotype changes involved in the early stage of disease. The tumors were all aneuploid and exhibited complex karyotypes with multiple structural and numerical abnormalities. Clonal structural rearrangements were identified and in particular loss of material from the short arm of chromosome 9 had a 90% incidence. This loss was due to non-reciprocal translocation, deletion, or chromosome loss. Breakpoints were in the region 9q13 to p22. Other chromosome regions that were non-randomly involved are as follows: I cen to p13, 3p, 5q11 to q13, 6p, 6q15 to q27, 7p, 8p, 11q12 to q23, 13p, 14p, 15p, 17p, and 19p. While a primary cytogenetic change in NSCLC has not been identified conclusively, our findings implicate loss of material from 9p as a potentially important event.
对10例原发性非小细胞肺癌（NSCLC）进行了细胞遗传学分析，其中包括5例腺癌（ADC）、3例鳞状细胞癌（SQC）和2例大细胞癌（LCC），旨在确定疾病早期阶段所涉及的核型变化。这些肿瘤均为非整倍体，呈现出具有多种结构和数量异常的复杂核型。识别出了克隆性结构重排，特别是9号染色体短臂物质缺失的发生率为90%。这种缺失是由于非相互易位、缺失或染色体丢失所致。断点位于9q13至p22区域。其他非随机受累的染色体区域如下：1号染色体着丝粒至p13、3p、5q11至q13、6p、6q15至q27、7p、8p、11q12至q23、13p、14p、15p、17p和19p。虽然尚未最终确定NSCLC的主要细胞遗传学变化，但我们的研究结果表明9p物质缺失可能是一个重要事件。
