Leibowitch M, Neill S, Pelisse M, Moyal-Baracco M
Service de Dermatologie, Hôpital Tarnier-Cochin, Université Paris V, France.
Br J Obstet Gynaecol. 1990 Dec;97(12):1135-9. doi: 10.1111/j.1471-0528.1990.tb02502.x.
Seventy-eight excised specimens of squamous cell carcinoma of the vulva were reviewed retrospectively for the presence of lichen sclerosus or vulvar intraepithelial neoplasia (VIN) at sites proximal to the tumour or more distant. Lichen sclerosus was evident in 61% and VIN alone in 31%. VIN III (differentiated) was associated with over 50% of the specimens with lichen sclerosus. HPV 16 was found in six of the 11 VIN lesions, investigated but in none of the six with lichen sclerosus.
对78例切除的外阴鳞状细胞癌标本进行回顾性研究，以确定肿瘤近端或更远部位是否存在硬化性苔藓或外阴上皮内瘤变（VIN）。61%的标本中有明显的硬化性苔藓，31%的标本仅有VIN。超过50%有硬化性苔藓的标本与VIN III（分化型）相关。在11例VIN病变标本中，有6例检测出HPV 16，但6例有硬化性苔藓的标本中均未检测到。
