Seidl S, Kühnl P, Beyer J, Stangel W, Flik J, Sibrowski W, Roos D, Bornhövd K, Kalmar G, Flacke H
Institut für Immunhämatologie, Universität Frankfurt.
Beitr Infusionsther. 1990;26:18-21.
A new EIA-test to detect Hepatitis C antibody (ORTHO Diagnostic Systems) has been evaluated in four blood transfusion services in FRG (Hamburg, Hannover, Springe, Frankfurt). Among 3,123 specimens, 18 (0.58%) reacted initially positive, 13 (0.42%) remained positive after repeat testing. A detailed analysis revealed remarkable differences: blood donors from the northern part of Germany were less frequently positive than donors from the southern region (0.24% vs. 0.79%), repeat donors had a higher HCV-antibody incidence than first-time donors (0.48% vs. 0.29%). Similar differences were observed between remunerated and non-remunerated donors (0.24% vs. 0.53%), as well as between donors from rural and urban areas (0.34% vs. 0.46%). In contrast to other investigators, only a weak correlation between elevated ALT-levels (greater than 50 IU/ml) and anti-HCV seropositivity rate has been found.
一种用于检测丙型肝炎抗体的新型酶免疫分析检测法（ORTHO诊断系统）在联邦德国的四个输血服务机构（汉堡、汉诺威、施普林格、法兰克福）进行了评估。在3123份样本中，18份（0.58%）最初检测呈阳性，13份（0.42%）在重复检测后仍为阳性。详细分析显示出显著差异：德国北部的献血者阳性率低于南部地区的献血者（0.24%对0.79%），再次献血者的丙肝抗体发生率高于首次献血者（0.48%对0.29%）。在有偿献血者和无偿献血者之间（0.24%对0.53%）以及农村和城市地区的献血者之间（0.34%对0.46%）也观察到了类似差异。与其他研究者不同，仅发现丙氨酸转氨酶水平升高（大于50 IU/ml）与抗丙肝血清阳性率之间存在微弱关联。
