• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Comparison of pharmacological effects of tetrahydrocannabinols and their 11-hydroxy-metabolites in mice.

作者信息

Watanabe K, Kijima T, Narimatsu S, Nishikami J, Yamamoto I, Yoshimura H

机构信息

Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1990 Aug;38(8):2317-9. doi: 10.1248/cpb.38.2317.

DOI:10.1248/cpb.38.2317
PMID:2177683
Abstract

Pharmacological effects (catalepsy, hypothermia, pentobarbital-induced sleep prolongation, anticonvulsant and analgesic effects) of delta 8- and delta 9-tetrahydrocannabinols, and their 11-hydroxy-metabolites were evaluated and compared in mice. delta 9-Tetrahydrocannabinol and 11-hydroxy-delta 9-tetrahydrocannabinol exhibited somewhat greater effects than did delta 8-tetrahydrocannabinol and 11-hydroxy-delta 8-tetrahydrocannabinol, respectively, in all pharmacological indices tested. Greater effects of 11-hydroxy-metabolites than those of tetrahydrocannabinols were also demonstrated.

摘要

相似文献

1
Comparison of pharmacological effects of tetrahydrocannabinols and their 11-hydroxy-metabolites in mice.
Chem Pharm Bull (Tokyo). 1990 Aug;38(8):2317-9. doi: 10.1248/cpb.38.2317.
2
Cross-tolerance development to the prolongation of pentobarbitone-induced sleep by delta 8-tetrahydrocannabinol and 11-hydroxy-delta 8-tetrahydrocannabinol in mice.
J Pharm Pharmacol. 1987 Nov;39(11):945-7. doi: 10.1111/j.2042-7158.1987.tb03136.x.
3
Difference in tolerance development of hypothermia and pentobarbital-induced sleep prolongating effect of 11-hydroxy-delta 8-tetrahydrocannabinol and 11-oxo-delta 8-tetrahydrocannabinol in mice.11-羟基-δ8-四氢大麻酚和11-氧代-δ8-四氢大麻酚对小鼠体温过低耐受性发展及戊巴比妥诱导睡眠延长作用的差异。
Eur J Pharmacol. 1982 Jan 8;77(1):53-6. doi: 10.1016/0014-2999(82)90535-0.
4
9 alpha, 10 alpha-epoxyhexahydrocannabinol formation from delta 9-tetrahydrocannabinol by liver microsomes of phenobarbital-treated mice and its pharmacological activities in mice.
J Pharmacobiodyn. 1983 Aug;6(8):558-64. doi: 10.1248/bpb1978.6.558.
5
Synthesis and pharmacological activities in mice of halogenated delta 9-tetrahydrocannabinol derivatives.卤代δ9-四氢大麻酚衍生物在小鼠体内的合成及药理活性
Chem Pharm Bull (Tokyo). 1998 Sep;46(9):1462-7. doi: 10.1248/cpb.46.1462.
6
Development of tolerance and cross-tolerance to the cataleptogenic effects of delta 8-tetrahydrocannabinol and 11-hydroxy-delta 8-tetrahydrocannabinol in mice.小鼠对δ8-四氢大麻酚和11-羟基-δ8-四氢大麻酚致僵效应的耐受性及交叉耐受性的发展
Eur J Pharmacol. 1983 Oct 28;94(3-4):349-51. doi: 10.1016/0014-2999(83)90427-2.
7
Cross-tolerance to the hypothermic effect of delta 8-tetrahydrocannabinol 11-hydroxy-delta 8-tetrahydrocannabinol and chlorpromazine in the mouse.小鼠对δ8-四氢大麻酚、11-羟基-δ8-四氢大麻酚和氯丙嗪低温效应的交叉耐受性。
Eur J Pharmacol. 1985 May 8;111(2):159-66. doi: 10.1016/0014-2999(85)90752-6.
8
Comparison in mice of pharmacological effects of delta 8-tetrahydrocannabinol and its metabolites oxidized at 11-position.
Eur J Pharmacol. 1980 Apr 11;63(1):1-6. doi: 10.1016/0014-2999(80)90110-7.
9
3'-Hydroxy- and (+/-)-3',11-dihydroxy-delta 9-tetrahydrocannabinol: biologically active metabolites of delta 9-tetrahydrocannabinol.
J Med Chem. 1982 Dec;25(12):1447-50. doi: 10.1021/jm00354a011.
10
Pharmacological activities in the mouse of delta 9-tetrahydrocannabinol metabolites oxidized at the 8-position.
Chem Pharm Bull (Tokyo). 1985 Jan;33(1):392-5. doi: 10.1248/cpb.33.392.

引用本文的文献

1
Examining impairment and kinetic patterns associated with recent use of hemp-derived Δ-tetrahydrocannabinol: case studies.研究与近期使用大麻衍生的Δ-四氢大麻酚相关的损伤和动力学模式：案例研究
J Cannabis Res. 2022 Jul 7;4(1):36. doi: 10.1186/s42238-022-00146-9.
2
Sex, species and age: Effects of rodent demographics on the pharmacology of ∆-tetrahydrocanabinol.性别、物种和年龄：啮齿动物人口统计学对 ∆-四氢大麻酚药理学的影响。
Prog Neuropsychopharmacol Biol Psychiatry. 2021 Mar 2;106:110064. doi: 10.1016/j.pnpbp.2020.110064. Epub 2020 Aug 15.
3
The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin.
三种植物大麻素：Δ⁹-四氢大麻酚、大麻二酚和Δ⁹-四氢大麻萜酚的不同CB1和CB2受体药理学特性
Br J Pharmacol. 2008 Jan;153(2):199-215. doi: 10.1038/sj.bjp.0707442. Epub 2007 Sep 10.