Nishiyama K, Shimizu J, Takeda K, Sakuta M
Department of Neurology, Japanese Red Cross Medical Center.
Rinsho Shinkeigaku. 1990 Oct;30(10):1140-2.
Two cases of painful alcoholic neuropathy are reported. The pain in both cases were incurable by using pain killing drugs, but administration of class Ib Na channel blocker, mexiletine, was remarkably effective. In the first case, suspension of drug administration produced the recurrence in the pain. Objective findings, for example, deep tendon reflex, vibration sense, and nerve conduction velocity, did not change significantly, after medication. And the only side effect was hot sensation in the lower extremities. We report the pain killing effect of class Ib Na channel blocker on painful alcoholic neuropathy, that has not yet reported.
报告了两例疼痛性酒精性神经病变病例。两例患者使用止痛药物均无法治愈疼痛，但给予Ib类钠通道阻滞剂美西律后效果显著。在第一例病例中，停药后疼痛复发。用药后，诸如深腱反射、振动觉和神经传导速度等客观检查结果并未显著改变。唯一的副作用是下肢有热感。我们报告了Ib类钠通道阻滞剂对疼痛性酒精性神经病变的止痛效果，此前尚未有相关报道。
