Nishiyama K, Sakuta M
Department of Neurology, School of Medicine, University of Tokyo.
Intern Med. 1995 Jun;34(6):577-9. doi: 10.2169/internalmedicine.34.577.
Five patients suffering from painful alcoholic neuropathy showed severe painful sensory disturbance in their extremities. Although their pain was not ameliorated by the typical usual analgesic agents, oral mexiletine (MX) therapy was remarkably effective for the pain (especially tingling and aching sensation) without major side effects. This study indicated that the minimum effective dose was 300 mg per day and the effective concentration of MX in plasma was 0.66 +/- 0.15 micrograms/ml in these patients. Thus, oral MX therapy can be a reliable treatment for pain in alcoholic neuropathy.
五名患有疼痛性酒精性神经病变的患者在其四肢表现出严重的疼痛性感觉障碍。尽管他们的疼痛并未通过典型的常用镇痛药得到缓解，但口服美西律（MX）疗法对疼痛（尤其是刺痛和酸痛感）非常有效，且无重大副作用。本研究表明，这些患者的最小有效剂量为每日300毫克，血浆中MX的有效浓度为0.66±0.15微克/毫升。因此，口服MX疗法可以成为治疗酒精性神经病变疼痛的可靠方法。
