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氰化物激发剂量-反应、时间进程及指示性毒性参数恢复情况的实验评估。

An experimental assessment of cyanide challenge dose-response, time-course and recovery of indicative toxicity parameters.

作者信息

Buzaleh A M, Vazquez E S, Batlle A M

机构信息

Centro de Investigaciones sobre Porfirinas y Porfirias CONICET, Facultad de Ciencias Exactas y Naturales, University of Buenos Aires, Argentina.

出版信息

Gen Pharmacol. 1990;21(6):839-43. doi: 10.1016/0306-3623(90)90442-o.

DOI:10.1016/0306-3623(90)90442-o
PMID:2177710
Abstract
  1. Several sub-lethal doses of cyanide were assayed with the aim of obtaining significant differences in the parameters studied. A dose of 4 mg/kg s.c. was selected. 2. Present studies were carried out to determine the time dependence of the effects produced by s.c. administration of a single dose of potassium cyanide as well as the recovery time of some of the toxicity indicative parameters. 3. It was found that cyanide effects continued for at least 3 days; after the parameters had recovered normal values.
摘要
  1. 测定了几个亚致死剂量的氰化物,目的是在所研究的参数上获得显著差异。选择了4毫克/千克皮下注射的剂量。2. 进行了目前的研究,以确定皮下注射单剂量氰化钾所产生的效应的时间依赖性以及一些毒性指示参数的恢复时间。3. 发现氰化物的效应持续了至少3天;在参数恢复到正常值之后。

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