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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Buzaleh A M, Vázquez E S, Batlle A M

Centro de Investigaciones sobre Porfirinas y Porfirias, CIPYP (CONICET, FCE y N, UBA), Ciudad Universitaria, Buenos Aires, Argentina.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1990;96(1):177-80. doi: 10.1016/0742-8413(90)90064-g.

Present studies were carried out to establish the action of cyanide maintained at a high level during a period as long as desired. 2. One of the earliest effects of cyanide seems to be the inhibition of hepatic rhodanese. These changes do not seem to occur in the blood. 3. Available cyanide labile-sulfur was always altered, unless cyanide tissue levels could not be detected. 4. The inhibitory action of cyanide on enzymatic reaction involving Schiff base intermediates was also corroborated through its effect on delta-aminolevulinate acid dehydratase activity. 5. S-Adenosyl-L-methionine was not able to modify the toxic cyanide action.

开展了当前这些研究，以确定在长达所需时长的一段时间内维持在高水平的氰化物的作用。2. 氰化物最早的作用之一似乎是抑制肝脏硫氰酸酶。这些变化似乎不会在血液中发生。3. 可用的氰化物不稳定硫总是会发生改变，除非无法检测到氰化物的组织水平。4. 氰化物对涉及席夫碱中间体的酶促反应的抑制作用也通过其对δ-氨基乙酰丙酸脱水酶活性的影响得到了证实。5. S-腺苷-L-甲硫氨酸无法改变氰化物的毒性作用。

Buzaleh A M, Vázquez E S, Batlle A M

Centro de Investigaciones sobre Porfirinas y Porfirias, CIPYP (CONICET, FCE y N, UBA), Ciudad Universitaria, Buenos Aires, Argentina.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1990;96(1):177-80. doi: 10.1016/0742-8413(90)90064-g.

Present studies were carried out to establish the action of cyanide maintained at a high level during a period as long as desired. 2. One of the earliest effects of cyanide seems to be the inhibition of hepatic rhodanese. These changes do not seem to occur in the blood. 3. Available cyanide labile-sulfur was always altered, unless cyanide tissue levels could not be detected. 4. The inhibitory action of cyanide on enzymatic reaction involving Schiff base intermediates was also corroborated through its effect on delta-aminolevulinate acid dehydratase activity. 5. S-Adenosyl-L-methionine was not able to modify the toxic cyanide action.

开展了当前这些研究，以确定在长达所需时长的一段时间内维持在高水平的氰化物的作用。2. 氰化物最早的作用之一似乎是抑制肝脏硫氰酸酶。这些变化似乎不会在血液中发生。3. 可用的氰化物不稳定硫总是会发生改变，除非无法检测到氰化物的组织水平。4. 氰化物对涉及席夫碱中间体的酶促反应的抑制作用也通过其对δ-氨基乙酰丙酸脱水酶活性的影响得到了证实。5. S-腺苷-L-甲硫氨酸无法改变氰化物的毒性作用。