维拉帕米长期给药对杜氏肌营养不良症的影响。

Effect of chronic administration of verapamil in Duchenne muscular dystrophy.

García A M, Goldemberg A L, Fernández H, Fortunato M, Ricci L, Trucco R E

Facultad de Ciencias Exactas y Naturales, U.N. de Mar del Plata, Argentina.

Gen Pharmacol. 1990;21(6):939-42. doi: 10.1016/0306-3623(90)90459-y.

Abstract

In DMD patients the effect of chronic treatment with verapamil was investigated in the p-nitrophenylphosphatase from erythrocytes, the CK and LDH in serum and the functional activity of the muscle. 2. A different behaviour in the p-nitrophenylphosphatase from untreated compared to treated DMD patients and controls is supported by the following findings: (a) values of "n" altered in F- inhibition of the enzyme with Hill coefficients -1.43, -2.18 and -2.19; (b) Arrhenius plots between 16 and 40 degrees C with inflection points for the enzyme from treated DMD patients and controls and not from untreated DMD patients. 3. Although CK and LDH in serum and the muscular evaluation showed no statistical difference between both groups, evidence is presented that in treated DMD patients the interaction membrane-enzyme is different from untreated DMD patients.

摘要

在杜氏肌营养不良症（DMD）患者中，研究了维拉帕米长期治疗对红细胞对硝基苯磷酸酶、血清中的肌酸激酶（CK）和乳酸脱氢酶（LDH）以及肌肉功能活性的影响。2. 以下研究结果支持了未治疗的DMD患者与治疗后的DMD患者及对照组相比，对硝基苯磷酸酶表现出不同行为：（a）在酶的F抑制中，“n”值改变，希尔系数分别为-1.43、-2.18和-2.19；（b）在16至40摄氏度之间的阿伦尼乌斯图，治疗后的DMD患者和对照组的酶有拐点，而未治疗的DMD患者的酶没有。3. 尽管两组患者血清中的CK和LDH以及肌肉评估无统计学差异，但有证据表明，治疗后的DMD患者中膜与酶的相互作用与未治疗的DMD患者不同。