4-硝基苯碱性磷酸酶在肌肉萎缩症中的抑制作用

4-Nitrophenylalkaline phosphatase inhibition in muscular dystrophy.

作者信息

Goldemberg A L, Sánchez J J, García A M, Fernández H, Fortunato M, Trucco R E

机构信息

Dpto. de Biología, Fac. de Ciencias Exactas y Naturales, Mar del Plata, Argentina.

出版信息

Clin Chim Acta. 1987 Aug 14;167(2):211-6. doi: 10.1016/0009-8981(87)90373-1.

DOI:10.1016/0009-8981(87)90373-1

PMID:2822292

Abstract

The allosteric behaviour of 4-nitrophenylphosphatase from membrane erythrocytes was investigated in Duchenne muscular dystrophy (DMD) patients, in female carriers and in healthy controls. Cooperative type kinetics with a Hill coefficient of -2.19, -1.71 and -1.54 has been obtained from the inhibition by fluoride in controls, female carriers and Duchenne patients, respectively. Our observation supports the previously described membrane abnormalities in DMD erythrocytes and may extend then to female carriers.

摘要

对杜兴氏肌营养不良症（DMD）患者、女性携带者和健康对照者的膜红细胞中4-硝基苯磷酸酶的变构行为进行了研究。在对照者、女性携带者和杜兴氏患者中，分别通过氟化物抑制获得了希尔系数为-2.19、-1.71和-1.54的协同型动力学。我们的观察结果支持了先前描述的DMD红细胞中的膜异常，并且可能进而扩展到女性携带者。