Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 60607, USA.
BMB Rep. 2011 Jul;44(7):435-45. doi: 10.5483/BMBRep.2011.44.7.435.
Serous ovarian cancer is one of the most lethal gynecological malignancies. Progress on effective diagnostics and therapeutics for this disease are hampered by ambiguity as to the cellular origins of this histotype of ovarian cancer, as well as limited suitable animal models to analyze early stages of disease. In this report, we will review current animal models with respect to the two proposed progenitor cells for serous ovarian cancer, the ovarian surface epithelium and the fallopian tube epithelium.
浆液性卵巢癌是最致命的妇科恶性肿瘤之一。这种卵巢癌组织学类型的细胞起源存在不确定性，以及缺乏合适的动物模型来分析疾病的早期阶段，这使得有效诊断和治疗该疾病的进展受到阻碍。在本报告中，我们将回顾目前关于浆液性卵巢癌的两种拟议祖细胞，即卵巢表面上皮细胞和输卵管上皮细胞的动物模型。
