Department of Biomedical Sciences, Research Institute of Molecular Genetics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
BMB Rep. 2011 Jul;44(7):478-83. doi: 10.5483/BMBRep.2011.44.7.478.
Hairless (HR), a transcriptional cofactor, is highly expressed in the skin and brain. To characterize the effects of HR expression in the skin, we examined its capacity for transcriptional regulation of its target genes in mouse skin and keratinocytes. We found that Foxe1 mRNA expression was suppressed in HR-overexpressing skin, as well as in HR-expressing keratinocytes. In turn, Msx1 expression was downregulated contingent on Foxe1 downregulation in skin and keratinocytes. We also found that expression of Sfrp1 was also correlated with that of Foxe1. Further investigation of the mechanisms involved in the transcriptional regulation of these genes will facilitate our understanding of the relationship among genes involved in hair follicle morphogenesis and cycling.
无毛（HR）是一种转录共因子，在皮肤和大脑中高度表达。为了研究 HR 在皮肤中的表达对其靶基因转录调控的影响，我们检测了其在小鼠皮肤和角质细胞中对靶基因的转录调控能力。我们发现 Foxe1mRNA 的表达在 HR 过表达的皮肤和 HR 表达的角质细胞中受到抑制。反过来，Foxe1 的下调导致 Msx1 在皮肤和角质细胞中的表达下调。我们还发现 Sfrp1 的表达与 Foxe1 的表达相关。进一步研究这些基因转录调控的机制将有助于我们理解参与毛囊形态发生和循环的基因之间的关系。
