Naval Medical Research Center, Infectious Diseases Directorate, Silver Spring, MD, United States.
Vaccine. 2011 Sep 23;29(42):7261-6. doi: 10.1016/j.vaccine.2011.07.019. Epub 2011 Jul 21.
Vaccination with plasmid DNA against infectious pathogens including dengue is an active area of investigation. By design, DNA vaccines are able to elicit both antibody responses and cellular immune responses capable of mediating long-term protection. Great technical improvements have been made in dengue DNA vaccine constructs and trials are underway to study these in the clinic. The scope of this review is to highlight the rich history of this vaccine platform and the work in dengue DNA vaccines accomplished by scientists at the Naval Medical Research Center. This work resulted in the only dengue DNA vaccine tested in a clinical trial to date. Additional advancements paving the road ahead in dengue DNA vaccine development are also discussed.
针对包括登革热在内的传染性病原体的疫苗接种是一个活跃的研究领域。从设计上讲，DNA 疫苗能够引起抗体反应和细胞免疫反应，从而提供长期保护。在登革热 DNA 疫苗构建方面取得了重大技术进步，目前正在进行临床试验研究。本文的重点是强调该疫苗平台的丰富历史以及海军医学研究中心的科学家在登革热 DNA 疫苗方面的工作。这一工作促成了迄今为止唯一一种在临床试验中测试的登革热 DNA 疫苗。还讨论了在登革热 DNA 疫苗开发方面的进一步进展。
