Unc93B1、TLR7 和 TLR9 之间的爱恨情仇阻止了致命的诱惑。
Love triangle between Unc93B1, TLR7, and TLR9 prevents fatal attraction.
机构信息
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
出版信息
Immunity. 2011 Jul 22;35(1):3-5. doi: 10.1016/j.immuni.2011.07.006.
Abstract
Unc93B1, a multitransmembrane ER-resident protein, controls intracellular trafficking of endosomal Toll-like receptors. In this issue of Immunity, Fukui et al. (2011) revealed that Unc93B1 regulates differential transport of TLR7 and TLR9 into signaling endosomes to prevent autoimmunity.
摘要
Unc93B1 是一种多跨膜内质网驻留蛋白，控制着内体 Toll 样受体的细胞内运输。在本期《免疫》杂志中，Fukui 等人（2011）揭示了 Unc93B1 调节 TLR7 和 TLR9 进入信号转导内体的差异运输，以防止自身免疫。
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本文引用的文献
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Immunity. 2011 Jul 22;35(1):69-81. doi: 10.1016/j.immuni.2011.05.010. Epub 2011 Jun 16.
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Bifurcation of Toll-like receptor 9 signaling by adaptor protein 3.衔接蛋白 3 对 Toll 样受体 9 信号的分支作用。
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TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus.TLR9 调节 TLR7 和 MyD88 依赖性自身抗体产生，并在狼疮小鼠模型中引发疾病。
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