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本文引用的文献

1
Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking.UNC93B1 通过协调 Toll 样受体 7 和 9 的运输来限制全身性致死性炎症。
Immunity. 2011 Jul 22;35(1):69-81. doi: 10.1016/j.immuni.2011.05.010. Epub 2011 Jun 16.
2
Bifurcation of Toll-like receptor 9 signaling by adaptor protein 3.衔接蛋白 3 对 Toll 样受体 9 信号的分支作用。
Science. 2010 Sep 17;329(5998):1530-4. doi: 10.1126/science.1187029.
3
TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus.TLR9 调节 TLR7 和 MyD88 依赖性自身抗体产生，并在狼疮小鼠模型中引发疾病。
J Immunol. 2010 Feb 15;184(4):1840-8. doi: 10.4049/jimmunol.0902592. Epub 2010 Jan 20.
4
A cell biological view of Toll-like receptor function: regulation through compartmentalization.Toll样受体功能的细胞生物学观点：通过区室化进行调节
Nat Rev Immunol. 2009 Aug;9(8):535-42. doi: 10.1038/nri2587. Epub 2009 Jun 26.
5
Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing.Unc93B1使树突状细胞中Toll样受体对核酸的反应偏向于识别DNA而非RNA。
J Exp Med. 2009 Jun 8;206(6):1339-50. doi: 10.1084/jem.20082316. Epub 2009 May 18.
6
UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes.UNC93B1将核苷酸感应型 toll 样受体递送至内溶酶体。
Nature. 2008 Mar 13;452(7184):234-8. doi: 10.1038/nature06726. Epub 2008 Feb 27.
7
Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation.Toll样受体7表达的调控对于限制自身免疫和树突状细胞增殖至关重要。
Immunity. 2007 Nov;27(5):801-10. doi: 10.1016/j.immuni.2007.09.009. Epub 2007 Nov 8.
8
Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease.具有免疫活性的自身抗原：Toll样受体在慢性炎症性疾病发生发展中的作用
Annu Rev Immunol. 2007;25:419-41. doi: 10.1146/annurev.immunol.22.012703.104514.
9
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.Toll样受体7和TLR9决定自身抗体特异性，并在狼疮小鼠模型中具有相反的炎症和调节作用。
Immunity. 2006 Sep;25(3):417-28. doi: 10.1016/j.immuni.2006.07.013.
10
A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus.一种新型小鼠有B细胞但缺乏血清抗体，揭示了B细胞在小鼠狼疮中不依赖抗体的作用。
J Exp Med. 1999 May 17;189(10):1639-48. doi: 10.1084/jem.189.10.1639.

Unc93B1、TLR7 和 TLR9 之间的爱恨情仇阻止了致命的诱惑。

Love triangle between Unc93B1, TLR7, and TLR9 prevents fatal attraction.

机构信息

Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

出版信息

Immunity. 2011 Jul 22;35(1):3-5. doi: 10.1016/j.immuni.2011.07.006.

DOI:10.1016/j.immuni.2011.07.006
PMID:21777792
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3143494/
Abstract

Unc93B1, a multitransmembrane ER-resident protein, controls intracellular trafficking of endosomal Toll-like receptors. In this issue of Immunity, Fukui et al. (2011) revealed that Unc93B1 regulates differential transport of TLR7 and TLR9 into signaling endosomes to prevent autoimmunity.

摘要

Unc93B1 是一种多跨膜内质网驻留蛋白，控制着内体 Toll 样受体的细胞内运输。在本期《免疫》杂志中，Fukui 等人（2011）揭示了 Unc93B1 调节 TLR7 和 TLR9 进入信号转导内体的差异运输，以防止自身免疫。