Desforges-Bullet V, Petit-Aubert G, Collet-Gaudillat C, Cerceau R, Fraleu-Louer B, Meckenstock R, Greder A, Cordoliani Y, Beressi J-P
Service d'endocrinologie-diabétologie, centre hospitalier de Versailles, 177, rue de Versailles, 78150 Le Chesnay, France.
Service d'endocrinologie-diabétologie, centre hospitalier de Versailles, 177, rue de Versailles, 78150 Le Chesnay, France.
Ann Endocrinol (Paris). 2011 Sep;72(4):304-309. doi: 10.1016/j.ando.2011.05.002. Epub 2011 Jul 21.
Thymus hyperplasia and Graves' disease association is not well known and is probably not incidental. We report the case of a young woman affected with Graves' disease in which a retrosternal mass was disclosed during a neck ultrasonographic-examination and confirmed by chest CT-examination. Follow-up ultrasound survey showed a decrease in the thymic mass size. Because of various antithyroid drugs allergy, a surgical procedure was performed, during which both her thyroid and thymic mass were removed. The histopathologic examination of this mass confirmed the hyperplasic nature of the thymic bulging. Ninety-one cases of thymus hyperplasia and Graves' disease association have been reported in literature, of which 20 were histologically confirmed. Among these cases 35 showed a thymic mass regression under medical treatment alone. Accordingly, surgical procedures are most frequently unnecessary in such associations because of the thymic mass decrease incurred by antithyroid drug treatment.
胸腺增生与格雷夫斯病的关联并不为人熟知，且可能并非偶然。我们报告一例患有格雷夫斯病的年轻女性病例，该患者在颈部超声检查时发现胸骨后肿块，胸部CT检查予以证实。随访超声检查显示胸腺肿块大小减小。由于对多种抗甲状腺药物过敏，遂进行了手术，术中切除了她的甲状腺和胸腺肿块。该肿块的组织病理学检查证实了胸腺隆起的增生性质。文献报道了91例胸腺增生与格雷夫斯病的关联病例，其中20例经组织学证实。在这些病例中，35例仅通过药物治疗就出现了胸腺肿块消退。因此，由于抗甲状腺药物治疗会使胸腺肿块减小，在这种关联中手术治疗通常没有必要。
