The VEGF165b "ICE-o-form" puts a chill on the VEGF story.
作者信息
Dokun Ayotunde O, Annex Brian H
出版信息
Circ Res. 2011 Jul 22;109(3):246-7. doi: 10.1161/CIRCRESAHA.111.249953.
Abstract
摘要
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1
The VEGF165b "ICE-o-form" puts a chill on the VEGF story.VEGF165b“ICE-o形式”给VEGF的情况带来了一丝寒意。
Circ Res. 2011 Jul 22;109(3):246-7. doi: 10.1161/CIRCRESAHA.111.249953.
2
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本文引用的文献
1
Overexpression of VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, leads to insufficient angiogenesis in patients with systemic sclerosis.血管内皮生长因子（VEGF）165b 的过表达是一种血管内皮生长因子的抑制性剪接变异体，可导致系统性硬化症患者的血管生成不足。
Circ Res. 2011 Jul 22;109(3):e14-26. doi: 10.1161/CIRCRESAHA.111.242057. Epub 2011 Jun 2.
2
Long-term blockade of vascular endothelial growth factor receptor-2 aggravates the diabetic renal dysfunction associated with inactivation of the Akt/eNOS-NO axis.长期阻断血管内皮生长因子受体-2 加重与 Akt/eNOS-NO 轴失活相关的糖尿病肾脏功能障碍。
Nephrol Dial Transplant. 2011 Apr;26(4):1173-88. doi: 10.1093/ndt/gfq610. Epub 2010 Oct 8.
3
Induction of podocyte VEGF164 overexpression at different stages of development causes congenital nephrosis or steroid-resistant nephrotic syndrome.在不同发育阶段诱导足细胞 VEGF164 过表达可导致先天性肾病或激素耐药性肾病综合征。
Am J Pathol. 2010 Nov;177(5):2225-33. doi: 10.2353/ajpath.2010.091146. Epub 2010 Sep 9.
4
The anti-angiogenic isoforms of VEGF in health and disease.血管内皮生长因子的抗血管生成异构体在健康和疾病中的作用。
Biochem Soc Trans. 2009 Dec;37(Pt 6):1207-13. doi: 10.1042/BST0371207.
5
Neutralization of vascular endothelial growth factor antiangiogenic isoforms is more effective than treatment with proangiogenic isoforms in stimulating vascular development and follicle progression in the perinatal rat ovary.在刺激围产期大鼠卵巢血管发育和卵泡进展方面，中和血管内皮生长因子抗血管生成异构体比用促血管生成异构体治疗更有效。
Biol Reprod. 2009 Nov;81(5):978-88. doi: 10.1095/biolreprod.109.078097. Epub 2009 Jul 15.
6
Plasma levels of soluble Tie2 and vascular endothelial growth factor distinguish critical limb ischemia from intermittent claudication in patients with peripheral arterial disease.可溶性Tie2和血管内皮生长因子的血浆水平可区分外周动脉疾病患者的严重肢体缺血和间歇性跛行。
J Am Coll Cardiol. 2008 Jul 29;52(5):387-93. doi: 10.1016/j.jacc.2008.02.045.
7
Impaired angiogenesis after hindlimb ischemia in type 2 diabetes mellitus: differential regulation of vascular endothelial growth factor receptor 1 and soluble vascular endothelial growth factor receptor 1.2型糖尿病患者后肢缺血后血管生成受损：血管内皮生长因子受体1和可溶性血管内皮生长因子受体1的差异调节
Circ Res. 2007 Oct 26;101(9):948-56. doi: 10.1161/CIRCRESAHA.107.160630. Epub 2007 Sep 6.
8
Expression of vascular endothelial growth factor, stromal cell-derived factor-1, and CXCR4 in human limb muscle with acute and chronic ischemia.血管内皮生长因子、基质细胞衍生因子-1及CXCR4在急性和慢性缺血人体肢体肌肉中的表达
Arterioscler Thromb Vasc Biol. 2007 Jun;27(6):1426-32. doi: 10.1161/ATVBAHA.107.139642. Epub 2007 Mar 15.
9
Targeting VEGF-A to treat cancer and age-related macular degeneration.靶向血管内皮生长因子-A治疗癌症和年龄相关性黄斑变性。
Annu Rev Med. 2007;58:491-504. doi: 10.1146/annurev.med.58.061705.145635.
10
Increased vascular endothelial growth factor expression but impaired vascular endothelial growth factor receptor signaling in the myocardium of type 2 diabetic patients with chronic coronary heart disease.2型糖尿病合并慢性冠心病患者心肌中血管内皮生长因子表达增加但血管内皮生长因子受体信号传导受损。
J Am Coll Cardiol. 2005 Sep 6;46(5):827-34. doi: 10.1016/j.jacc.2005.06.007.
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