The actions of 2-hydroxy-saclofen at presynaptic GABAB receptors in the rat hippocampus.
作者信息
Harrison N L, Lovinger D M, Lambert N A, Teyler T J, Prager R, Ong J, Kerr D I
机构信息
Department of Anesthesia and Critical Care, University of Chicago, IL 60637.
出版信息
Neurosci Lett. 1990 Nov 13;119(2):272-6. doi: 10.1016/0304-3940(90)90851-y.
The actions of 2-hydroxy-saclofen (2-OH-S), a recently developed analog of baclofen, were studied at presynaptic GABAB receptors in the rat hippocampal slice. Baclofen (0.5-20 microM) reduces the amplitude of excitatory postsynaptic potentials (EPSPs) recorded from hippocampal CA1 pyramidal neurons. In the presence of 200-500 microM 2-OH-S, the synaptic depressant action of baclofen is significantly reduced. These data show that 2-OH-S is an effective antagonist at presynaptic GABAB receptors on excitatory terminals in the hippocampus.
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