癌症中的趋化作用。
Chemotaxis in cancer.
机构信息
Department of Anatomy and Structural Biology, Program in Tumor Microenvironment and Metastasis, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA.
出版信息
Nat Rev Cancer. 2011 Jul 22;11(8):573-87. doi: 10.1038/nrc3078.
Abstract
Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an essential component of tumour dissemination during progression and metastasis. This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulate chemotaxis in tumour cells and how chemotaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread. The central importance of chemotaxis in cancer progression is highlighted by discussion of the use of chemotaxis as a prognostic marker, a treatment end point and a target of therapeutic intervention.
摘要
肿瘤细胞和周围微环境中的基质细胞的趋化作用是肿瘤进展和转移过程中肿瘤扩散的一个重要组成部分。本综述总结了趋化作用如何指导肿瘤细胞和基质细胞在体内的不同行为，分子途径如何调节肿瘤细胞的趋化作用，以及趋化作用如何编排细胞行为以塑造肿瘤微环境并决定转移扩散。通过讨论趋化作用作为预后标志物、治疗终点和治疗干预靶点，突出了趋化作用在癌症进展中的核心重要性。
相似文献
1
Chemotaxis in cancer.癌症中的趋化作用。
Nat Rev Cancer. 2011 Jul 22;11(8):573-87. doi: 10.1038/nrc3078.
2
CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion.CXCR4-SDF-1信号传导、运动、趋化性和黏附
J Mol Histol. 2004 Mar;35(3):233-45. doi: 10.1023/b:hijo.0000032355.66152.b8.
3
RET isoform-specific interaction with scaffold protein Ezrin promotes cell migration and chemotaxis in lung adenocarcinoma.RET 异构体与支架蛋白 Ezrin 的特异性相互作用促进肺腺癌的细胞迁移和趋化性。
Lung Cancer. 2020 Apr;142:123-131. doi: 10.1016/j.lungcan.2020.02.004. Epub 2020 Feb 22.
4
CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment.CXCR4：肿瘤细胞与其微环境相互作用中的关键受体。
Blood. 2006 Mar 1;107(5):1761-7. doi: 10.1182/blood-2005-08-3182. Epub 2005 Nov 3.
5
CAIX furthers tumour progression in the hypoxic tumour microenvironment of esophageal carcinoma and is a possible therapeutic target.CAIX 促进食管癌缺氧肿瘤微环境中的肿瘤进展，是一个可能的治疗靶点。
J Enzyme Inhib Med Chem. 2018 Dec;33(1):1024-1033. doi: 10.1080/14756366.2018.1475369.
6
Is carcinoma a mesenchymal disease? The role of the stromal microenvironment in carcinogenesis.癌是间叶组织疾病吗？基质微环境在肿瘤发生中的作用。
Pathology. 2013 Jun;45(4):371-81. doi: 10.1097/PAT.0b013e328360b600.
7
Royal Society Scientific Meeting: Extracellular vesicles in the tumour microenvironment.英国皇家学会科学会议：肿瘤微环境中的细胞外囊泡。
Philos Trans R Soc Lond B Biol Sci. 2018 Jan 5;373(1737). doi: 10.1098/rstb.2017.0066.
8
CC chemokine receptor-like 1 functions as a tumour suppressor by impairing CCR7-related chemotaxis in hepatocellular carcinoma.CC趋化因子受体样1通过损害肝细胞癌中与CCR7相关的趋化作用发挥肿瘤抑制功能。
J Pathol. 2015 Mar;235(4):546-58. doi: 10.1002/path.4450. Epub 2014 Dec 18.
9
Core-shell nanoparticles suppress metastasis and modify the tumour-supportive activity of cancer-associated fibroblasts.核壳纳米粒子抑制转移并改变肿瘤相关成纤维细胞的肿瘤支持活性。
J Nanobiotechnology. 2020 Jan 21;18(1):18. doi: 10.1186/s12951-020-0576-x.
10
Molecular insights into prostate cancer progression: the missing link of tumor microenvironment.前列腺癌进展的分子见解：肿瘤微环境的缺失环节
J Urol. 2005 Jan;173(1):10-20. doi: 10.1097/01.ju.0000141582.15218.10.
引用本文的文献
1
Protopanaxatriol, a ginsenoside metabolite, induces apoptosis in colorectal cancer cells and arrests their cell cycle by targeting AKT.原人参三醇，一种人参皂苷代谢产物，通过靶向AKT诱导结肠癌细胞凋亡并使其细胞周期停滞。
J Ginseng Res. 2025 Sep;49(5):488-501. doi: 10.1016/j.jgr.2025.03.012. Epub 2025 Apr 3.
2
MCP-1-CCR2-M2 macrophages axis contributes to diffuse large B-cell lymphoma progression and inhibits antitumor immune response.MCP-1-CCR2-M2巨噬细胞轴促进弥漫性大B细胞淋巴瘤进展并抑制抗肿瘤免疫反应。
Sci Rep. 2025 Aug 8;15(1):29044. doi: 10.1038/s41598-025-14527-6.
3
Single-Cell Transcriptomic Analysis Unveils Key Regulators and Signaling Pathways in Lung Adenocarcinoma Progression.单细胞转录组分析揭示肺腺癌进展中的关键调节因子和信号通路。
Biomedicines. 2025 Jun 30;13(7):1606. doi: 10.3390/biomedicines13071606.
4
Approximate Bayesian inference in a model for self-generated gradient collective cell movement.自生成梯度集体细胞运动模型中的近似贝叶斯推理。
Comput Stat. 2025;40(7):3399-3452. doi: 10.1007/s00180-025-01606-5. Epub 2025 Mar 8.
5
Prospective study of cesarean scar pregnancy associated with increased MCP-1 and cholesterol synthesis.剖宫产瘢痕妊娠与MCP-1及胆固醇合成增加相关性的前瞻性研究
Biomed Rep. 2025 Jun 26;23(3):148. doi: 10.3892/br.2025.2026. eCollection 2025 Sep.
6
Guanosine-Based Supramolecular Particles for Enhanced Drug and Gene Delivery in Cell Culture.用于增强细胞培养中药物和基因递送的基于鸟苷的超分子颗粒
ACS Appl Bio Mater. 2025 Jul 21;8(7):5625-5633. doi: 10.1021/acsabm.5c00201. Epub 2025 Jun 10.
7
Collective migration modes in development, tissue repair and cancer.发育、组织修复和癌症中的集体迁移模式。
Nat Rev Mol Cell Biol. 2025 Jun 5. doi: 10.1038/s41580-025-00858-9.
8
Invadopodia in cancer metastasis: dynamics, regulation, and targeted therapies.癌症转移中的侵袭性伪足：动力学、调控及靶向治疗
J Transl Med. 2025 May 16;23(1):548. doi: 10.1186/s12967-025-06526-y.
9
Mixed lineage kinase (MLK) controls tumor development and angiogenesis.混合谱系激酶（MLK）控制肿瘤发展和血管生成。
Angiogenesis. 2025 May 2;28(3):29. doi: 10.1007/s10456-025-09978-4.
10
Impact of self-expandable metallic prosthesis on lymph node dissemination in obstructive left-sided colorectal cancer.自膨式金属支架对梗阻性左侧结直肠癌淋巴结扩散的影响
Surg Endosc. 2025 May;39(5):3224-3235. doi: 10.1007/s00464-025-11652-1. Epub 2025 Apr 14.
本文引用的文献
1
Setup and use of a two-laser multiphoton microscope for multichannel intravital fluorescence imaging.建立和使用双激光多光子显微镜进行多通道活细胞荧光成像。
Nat Protoc. 2011 Sep 8;6(10):1500-20. doi: 10.1038/nprot.2011.376.
2
Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer.Mena 入侵（MenaINV）促进乳腺癌小鼠模型中的多细胞流动力和跨内皮迁移。
J Cell Sci. 2011 Jul 1;124(Pt 13):2120-31. doi: 10.1242/jcs.086231.
3
Mena invasive (Mena(INV)) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM.Mena 侵袭（Mena(INV)）和 Mena11a 异构体在乳腺癌细胞黏附和与 TMEM 相关联方面发挥不同的作用。
Clin Exp Metastasis. 2011 Aug;28(6):515-27. doi: 10.1007/s10585-011-9388-6. Epub 2011 Apr 12.
4
A novel spatiotemporal RhoC activation pathway locally regulates cofilin activity at invadopodia.一种新的时空 RhoC 激活途径局部调节侵袭伪足处的肌动蛋白丝解聚因子的活性。
Curr Biol. 2011 Apr 26;21(8):635-44. doi: 10.1016/j.cub.2011.03.039. Epub 2011 Apr 7.
5
Efficient generation of gene knockout plasmids for Dictyostelium discoideum using one-step cloning.一步克隆法高效生成基因敲除质粒用于盘基网柄菌。
Genomics. 2011 May;97(5):321-5. doi: 10.1016/j.ygeno.2011.02.001. Epub 2011 Feb 19.
6
An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion.EGFR-Src-Arg-cortactin 通路介导侵袭伪足的功能成熟和乳腺癌细胞侵袭。
Cancer Res. 2011 Mar 1;71(5):1730-41. doi: 10.1158/0008-5472.CAN-10-1432. Epub 2011 Jan 21.
7
mTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion.mTORC2 通过 cAMP 和 RhoA 依赖的方式调节中性粒细胞趋化性。
Dev Cell. 2010 Dec 14;19(6):845-57. doi: 10.1016/j.devcel.2010.11.004.
8
Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors.Mena 缺乏可延迟多瘤病毒中 T 抗原转基因鼠乳腺肿瘤的进展并减少转移。
Breast Cancer Res. 2010;12(6):R101. doi: 10.1186/bcr2784. Epub 2010 Nov 25.
9
Does tumour dormancy offer a therapeutic target?肿瘤休眠是否提供了治疗靶点？
Nat Rev Cancer. 2010 Dec;10(12):871-7. doi: 10.1038/nrc2933. Epub 2010 Nov 4.
10
An arrayed high-content chemotaxis assay for patient diagnosis.用于患者诊断的高通量高内涵化学趋药性分析检测法。
Integr Biol (Camb). 2010 Nov;2(11-12):630-8. doi: 10.1039/c0ib00030b. Epub 2010 Oct 18.
Zotero 插件