Department of Anatomy and Structural Biology, Program in Tumor Microenvironment and Metastasis, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA.
Nat Rev Cancer. 2011 Jul 22;11(8):573-87. doi: 10.1038/nrc3078.
Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an essential component of tumour dissemination during progression and metastasis. This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulate chemotaxis in tumour cells and how chemotaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread. The central importance of chemotaxis in cancer progression is highlighted by discussion of the use of chemotaxis as a prognostic marker, a treatment end point and a target of therapeutic intervention.
肿瘤细胞和周围微环境中的基质细胞的趋化作用是肿瘤进展和转移过程中肿瘤扩散的一个重要组成部分。本综述总结了趋化作用如何指导肿瘤细胞和基质细胞在体内的不同行为，分子途径如何调节肿瘤细胞的趋化作用，以及趋化作用如何编排细胞行为以塑造肿瘤微环境并决定转移扩散。通过讨论趋化作用作为预后标志物、治疗终点和治疗干预靶点，突出了趋化作用在癌症进展中的核心重要性。
