从鸡舍到病床边：追溯花房从禽白血病病毒到SRC再到ABL及其他的遗产。
From Hen House to Bedside: Tracing Hanafusa's Legacy from Avian Leukemia Viruses to SRC to ABL and Beyond.
作者信息
Kharas Michael G, Daley George Q
机构信息
Division of Hematology, Brigham and Women's Hospital, Boston, MA, USA.
出版信息
Genes Cancer. 2010 Dec;1(12):1164-9. doi: 10.1177/1947601911407327.
Abstract
The discovery of the Src oncogene was the first step on a long journey toward improved cancer chemotherapy. In this review, we explore Src and BCR-ABL, signal transduction, and recent advances in oncogene addiction and celebrate Hidesaboro Hanafusa and the many researchers who ushered in the age of target-directed therapy against tyrosine kinase oncoproteins.
摘要
Src癌基因的发现是朝着改善癌症化疗的漫长征程迈出的第一步。在这篇综述中，我们探讨Src和BCR-ABL、信号转导以及癌基因成瘾方面的最新进展，并赞颂花房秀三郎以及众多开启针对酪氨酸激酶癌蛋白的靶向治疗时代的研究人员。
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