酵母中的Ras信号传导。
Ras signaling in yeast.
作者信息
Tamanoi Fuyuhiko
机构信息
Department of Microbiology, Immunology & Molecular Genetics, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA, USA.
出版信息
Genes Cancer. 2011 Mar;2(3):210-5. doi: 10.1177/1947601911407322.
Abstract
Since the study of yeast RAS and adenylate cyclase in the early 1980s, yeasts including budding and fission yeasts contributed significantly to the study of Ras signaling. First, yeast studies provided insights into how Ras activates downstream signaling pathways. Second, yeast studies contributed to the identification and characterization of GAP and GEF proteins, key regulators of Ras. Finally, the study of yeast provided many important insights into the understanding of C-terminal processing and membrane association of Ras proteins.
摘要
自20世纪80年代初对酵母RAS和腺苷酸环化酶进行研究以来，包括芽殖酵母和裂殖酵母在内的酵母对Ras信号传导的研究做出了重大贡献。首先，酵母研究为Ras如何激活下游信号通路提供了见解。其次，酵母研究有助于鉴定和表征Ras的关键调节因子GAP和GEF蛋白。最后，酵母研究为理解Ras蛋白的C末端加工和膜结合提供了许多重要见解。
相似文献
1
Ras signaling in yeast.酵母中的Ras信号传导。
Genes Cancer. 2011 Mar;2(3):210-5. doi: 10.1177/1947601911407322.
2
The SH3 domain of the S. cerevisiae Cdc25p binds adenylyl cyclase and facilitates Ras regulation of cAMP signalling.酿酒酵母Cdc25p的SH3结构域与腺苷酸环化酶结合，并促进Ras对cAMP信号的调控。
Cell Signal. 1999 Feb;11(2):127-35. doi: 10.1016/s0898-6568(98)00044-8.
3
Homologous activators of ras in fission and budding yeast.裂殖酵母和芽殖酵母中ras的同源激活因子。
Nature. 1990 Mar 22;344(6264):355-7. doi: 10.1038/344355a0.
4
Localization of Ras signaling complex in budding yeast.Ras信号复合物在芽殖酵母中的定位。
Biochim Biophys Acta. 2012 Jul;1823(7):1208-16. doi: 10.1016/j.bbamcr.2012.04.016. Epub 2012 May 7.
5
The C-terminal part of the CDC25 gene product plays a key role in signal transduction in the glucose-induced modulation of cAMP level in Saccharomyces cerevisiae.CDC25基因产物的C末端部分在酿酒酵母中葡萄糖诱导的cAMP水平调节的信号转导中起关键作用。
Eur J Biochem. 1990 Nov 13;193(3):675-80. doi: 10.1111/j.1432-1033.1990.tb19386.x.
6
[Yeast and the control of RAS by exchange factors].
C R Seances Soc Biol Fil. 1995;189(1):13-24.
7
[Ras proteins in Saccharomyces cerevisiae, their partners and their activation].[酿酒酵母中的Ras蛋白、其伙伴及其激活]
C R Seances Soc Biol Fil. 1997;191(2):221-35.
8
Evidence for adenylate cyclase as a scaffold protein for Ras2-Ira interaction in Saccharomyces cerevisie.腺苷酸环化酶作为酿酒酵母中Ras2-Ira相互作用的支架蛋白的证据。
Cell Signal. 2014 May;26(5):1147-54. doi: 10.1016/j.cellsig.2014.02.001. Epub 2014 Feb 8.
9
Involvement of the CDC25 gene product in the signal transmission pathway of the glucose-induced RAS-mediated cAMP signal in the yeast Saccharomyces cerevisiae.CDC25基因产物参与酿酒酵母中葡萄糖诱导的RAS介导的cAMP信号的信号转导途径。
J Gen Microbiol. 1991 Feb;137(2):341-9. doi: 10.1099/00221287-137-2-341.
10
The posttranslational processing of ras p21 is critical for its stimulation of yeast adenylate cyclase.ras p21的翻译后加工对于其刺激酵母腺苷酸环化酶至关重要。
Mol Cell Biol. 1992 Oct;12(10):4515-20. doi: 10.1128/mcb.12.10.4515-4520.1992.
引用本文的文献
1
Functional and structural insights into RAS effector proteins.RAS 效应蛋白的功能和结构见解。
Mol Cell. 2024 Aug 8;84(15):2807-2821. doi: 10.1016/j.molcel.2024.06.027. Epub 2024 Jul 17.
2
Effects of CO in fungi.真菌中的一氧化碳效应。
Curr Opin Microbiol. 2024 Jun;79:102488. doi: 10.1016/j.mib.2024.102488. Epub 2024 May 17.
3
The Ras GTPase-activating protein UvGap1 orchestrates conidiogenesis and pathogenesis in the rice false smut fungus Ustilaginoidea virens.Ras GTPase 激活蛋白 UvGap1 调控水稻黑粉菌 Ustilaginoidea virens 的分生孢子发生和致病性。
Mol Plant Pathol. 2024 Mar;25(3):e13448. doi: 10.1111/mpp.13448.
4
The intricate role of Sir2 in oxidative stress response during the post-diauxic phase in .Sir2在[具体生物]的二次生长后期氧化应激反应中的复杂作用。 （注：原文中“in.”后内容缺失，这里根据已有内容翻译并补充了一个通用的“[具体生物]”）
Front Microbiol. 2023 Nov 9;14:1285559. doi: 10.3389/fmicb.2023.1285559. eCollection 2023.
5
Deciphering the regulatory mechanisms of the cAMP/protein kinase A pathway and their roles in the pathogenicity of .解析环磷酸腺苷/蛋白激酶A信号通路的调控机制及其在……致病性中的作用
Microbiol Spectr. 2023 Sep 6;11(5):e0215223. doi: 10.1128/spectrum.02152-23.
6
A comprehensive in vivo screen of yeast farnesyltransferase activity reveals broad reactivity across a majority of CXXX sequences.酵母法尼基转移酶活性的综合体内筛选揭示了大多数 CXXX 序列的广泛反应性。
G3 (Bethesda). 2023 Jul 5;13(7). doi: 10.1093/g3journal/jkad094.
7
Specific Disruption of Ras2 CAAX Proteolysis Alters Its Localization and Function.特定的 Ras2 CAAX 蛋白水解作用破坏会改变其定位和功能。
Microbiol Spectr. 2023 Feb 14;11(1):e0269222. doi: 10.1128/spectrum.02692-22. Epub 2023 Jan 5.
8
Yeast Protein Kinase A Isoforms: A Means of Encoding Specificity in the Response to Diverse Stress Conditions?酵母蛋白激酶 A 同工型：在应对不同胁迫条件时特异性编码的一种手段？
Biomolecules. 2022 Jul 8;12(7):958. doi: 10.3390/biom12070958.
9
Synthetic Vulnerabilities in the KRAS Pathway.KRAS 信号通路中的合成脆弱性
Cancers (Basel). 2022 Jun 8;14(12):2837. doi: 10.3390/cancers14122837.
10
Breadth and Specificity in Pleiotropic Protein Kinase A Activity and Environmental Responses.多效性蛋白激酶A活性与环境反应中的广度和特异性
Front Cell Dev Biol. 2022 Feb 16;10:803392. doi: 10.3389/fcell.2022.803392. eCollection 2022.
本文引用的文献
1
Deregulated Ras signaling compromises DNA damage checkpoint recovery in S. cerevisiae.Ras 信号失调会损害酿酒酵母中 DNA 损伤检查点的恢复。
Cell Cycle. 2010 Aug 15;9(16):3353-63. doi: 10.4161/cc.9.16.12713. Epub 2010 Aug 17.
2
Serine214 of Ras2p plays a role in the feedback regulation of the Ras-cAMP pathway in the yeast Saccharomyces cerevisiae.Ras2p 丝氨酸 214 参与酵母酿酒酵母 Ras-cAMP 途径的反馈调节。
FEBS Lett. 2010 Jun 3;584(11):2333-8. doi: 10.1016/j.febslet.2010.04.011. Epub 2010 Apr 11.
3
Functional oligomerization of the Saccharomyces cerevisiae isoprenylcysteine carboxyl methyltransferase, Ste14p.酿酒酵母异戊烯基半胱氨酸羧基甲基转移酶 Ste14p 的功能寡聚化。
J Biol Chem. 2010 Apr 30;285(18):13380-7. doi: 10.1074/jbc.M109.061366. Epub 2010 Mar 3.
4
The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans.酵母中的 RasGAP 蛋白 Ira2 和神经纤维瘤抑制蛋白受 Gpb1 的负调控，人类中的 ETEA 也有此作用。
Mol Cell Biol. 2010 May;30(9):2264-79. doi: 10.1128/MCB.01450-08. Epub 2010 Feb 16.
5
Deterministic mathematical models of the cAMP pathway in Saccharomyces cerevisiae.酿酒酵母中cAMP信号通路的确定性数学模型。
BMC Syst Biol. 2009 Jul 16;3:70. doi: 10.1186/1752-0509-3-70.
6
The Ras/cAMP pathway and the CDK-like kinase Ime2 regulate the MAPK Smk1 and spore morphogenesis in Saccharomyces cerevisiae.Ras/cAMP信号通路和类周期蛋白依赖性激酶Ime2调节酿酒酵母中的丝裂原活化蛋白激酶Smk1和孢子形态发生。
Genetics. 2009 Feb;181(2):511-23. doi: 10.1534/genetics.108.098434. Epub 2008 Dec 15.
7
Amino acid transport through the Saccharomyces cerevisiae Gap1 permease is controlled by the Ras/cAMP pathway.氨基酸通过酿酒酵母Gap1通透酶的转运受Ras/cAMP途径调控。
Int J Biochem Cell Biol. 2008;40(3):496-502. doi: 10.1016/j.biocel.2007.08.012. Epub 2007 Aug 30.
8
Kelch-repeat proteins interacting with the Galpha protein Gpa2 bypass adenylate cyclase for direct regulation of protein kinase A in yeast.与Gα蛋白Gpa2相互作用的Kelch重复蛋白绕过腺苷酸环化酶，直接调节酵母中的蛋白激酶A。
Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13034-9. doi: 10.1073/pnas.0509644103. Epub 2006 Aug 21.
9
The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2.kelch蛋白Gpb1和Gpb2通过与酵母RasGAP神经纤维瘤蛋白同源物Ira1和Ira2结合来抑制Ras活性。
Mol Cell. 2006 Jun 23;22(6):819-830. doi: 10.1016/j.molcel.2006.05.011.
10
Compartmentalized signaling of Ras in fission yeast.裂殖酵母中Ras的区室化信号传导。
Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9045-50. doi: 10.1073/pnas.0603318103. Epub 2006 Jun 5.
Zotero 插件