Department of Applied Bioorganic Chemistry, Gifu University, 1-1 Yanagido, Gifu-shi, Gifu 501-1193, Japan.
Chem Commun (Camb). 2011 Sep 14;47(34):9726-8. doi: 10.1039/c1cc13200h. Epub 2011 Jul 21.
The glycan moiety of ganglioside HPG-7, isolated from the sea cucumber (Holothuria pervicax), was synthesized for the first time. The characteristic substructure, a trisialic acid sequence embedded in the glycan, was deliberately constructed by utilizing suitably differentiated sialyl units for various synthetic purposes. Finally, a pentasaccharide was successfully delivered as the hexyl glycoside.
首次对从海参（Holothuria pervicax）中分离得到的神经节苷脂 HPG-7 的糖基部分进行了合成。该特征亚结构是通过利用适当区分的唾液酸单元来实现各种合成目的，故意构建在聚糖中的三唾液酸序列。最后，成功地将五糖作为己基糖苷进行了递送。
