Centre for Molecular Nanometrology, WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, UK.
Analyst. 2011 Oct 7;136(19):3831-53. doi: 10.1039/c1an15452d. Epub 2011 Jul 21.
Surface enhancement can provide improved detection sensitivity in a range of optical spectroscopies. When applied to bioanalysis these enhanced techniques allow for the detection of disease biomarkers at lower levels, which has a clear patient benefit. However, to achieve widespread clinical use of surface enhanced techniques there remain several "grand challenges". In this review we consider the substrates employed to achieve enhancement before reviewing each enhanced optical technique in detail; surface plasmon resonance, localised surface plasmon resonance, surface enhanced fluorescence, surface enhanced infrared absorption spectroscopy and surface enhanced (resonance) Raman spectroscopy. Finally we set out the "grand challenges" currently facing the field.
表面增强可以在多种光谱技术中提供更高的检测灵敏度。当应用于生物分析时，这些增强技术可以在更低的水平检测到疾病生物标志物，这对患者有明显的益处。然而，要实现表面增强技术的广泛临床应用，仍然存在一些“重大挑战”。在本文中，我们首先考虑了用于实现增强的衬底，然后详细回顾了每种增强的光学技术：表面等离子体共振、局域表面等离子体共振、表面增强荧光、表面增强红外吸收光谱和表面增强（共振）拉曼光谱。最后，我们列出了该领域目前面临的“重大挑战”。
