Schade Lilian, Paiva Eduardo Dos Santos, Müller Carolina de Souza
Service of Rheumatology of the Hospital de Clínicas of the Universidade Federal do Paraná (HC-UFPR), Brazil.
Rev Bras Reumatol. 2011 Jul-Aug;51(4):309-10, 313.
Patients with systemic sclerosis (SSc) can have muscle involvement in the form of myositis or non-infl ammatory myopathy. The muscle involvement can be associated with left ventricular dysfunction (LVD) in patients with SSc, resulting in worse prognosis. Eighty-seven patients of the Hospital de Clínicas of the Universidade Federal do Paraná, diagnosed with SSc, were assessed regarding the presence of skeletal muscle manifestations and their relation with LVD. A 42.5% prevalence of muscle involvement was observed in the patients studied, as well as a positive correlation with the diffuse form of the disease. Excluding other causes of LVD, three of the four patients with ejection fraction below the normal reference value had alteration of the muscle strength, atrophy and/or serum creatine phosphokinase (CPK) elevation.
系统性硬化症（SSc）患者可出现肌炎或非炎性肌病形式的肌肉受累。肌肉受累可与SSc患者的左心室功能障碍（LVD）相关，导致预后更差。对巴拉那联邦大学临床医院诊断为SSc的87例患者进行了骨骼肌表现及其与LVD关系的评估。在所研究的患者中观察到肌肉受累的患病率为42.5%，并且与疾病的弥漫型呈正相关。排除LVD的其他原因后，射血分数低于正常参考值的4例患者中有3例存在肌力改变、萎缩和/或血清肌酸磷酸激酶（CPK）升高。
