Skare Thelma Larocca, Nakano Irene, Escuissiato Dante Luiz, Batistetti Renato, Rodrigues Tales de Oliveira, Silva Marília Barreto
Service of Rheumatology of the Hospital Universitário Evangélico de Curitiba, state of Paraná, Brazil.
Rev Bras Reumatol. 2011 Jul-Aug;51(4):325-30, 336-7.
Extra-articular manifestations are found in up to 50% of the patients with rheumatoid arthritis (RA).
To assess the prevalence of pulmonary changes on high-resolution computed tomography (HRCT) in patients with RA and their association with demographic, clinical, serological and therapeutic variables.
Seventy-one patients with RA were assessed regarding their age at RA onset, duration of disease, gender, tobacco use, presence of rheumatoid nodules, secondary Sjögren's syndrome, rheumatoid factor, presence of anti-CCP and antinuclear factor, respiratory complaints, use of medications, and pulmonary changes on HRCT.
HRCT changes were identified in 55% of the patients, the most common being the presence of ground glass opacities, parenchymal bands, traction bronchiectasis, and honeycombing. None of the clinical variables studied associated with the HRCT findings, except for duration of the disease, which was longer in patients with pulmonary nodules and reticular lesions (ground-glass opacity).
There is a high prevalence of HRCT changes in patients with RA, which do not associate with clinical, serological, therapeutic and demographic variables, except for duration of disease.
类风湿关节炎（RA）患者中，高达50%会出现关节外表现。
评估RA患者高分辨率计算机断层扫描（HRCT）上肺部改变的患病率及其与人口统计学、临床、血清学和治疗变量的关联。
对71例RA患者评估其RA发病年龄、病程、性别、吸烟情况、类风湿结节的存在、继发性干燥综合征、类风湿因子、抗环瓜氨酸肽抗体和抗核因子的存在、呼吸道症状、药物使用情况以及HRCT上的肺部改变。
55%的患者发现有HRCT改变，最常见的是磨玻璃影、实质条索、牵拉性支气管扩张和蜂窝肺。除病程外，所研究的临床变量均与HRCT表现无关，病程在有肺结节和网状病变（磨玻璃影）的患者中更长。
RA患者HRCT改变的患病率很高，除病程外，与临床、血清学、治疗和人口统计学变量无关。
