Kelmenson Lindsay B, Demoruelle M Kristen, Deane Kevin D
Division of Rheumatology, University of Colorado Denver, 1635 Aurora Court, MS F721, Aurora, CO, 80045, USA.
Denver Veterans Affairs Medical Center, Denver, CO, USA.
Curr Rheumatol Rep. 2016 Nov;18(11):69. doi: 10.1007/s11926-016-0618-4.
While the primary manifestation of rheumatoid arthritis (RA) is articular disease, extra-articular disease may also occur. In particular, pulmonary disease is a frequent extra-articular manifestation of seropositive RA and a leading cause of morbidity and mortality in this population. This review will highlight studies published in the last several years and will, in particular, discuss the relationship of antibodies to citrullinated protein/peptide antigens (ACPA) and lung disease in patients with RA. We will also review the data regarding the potential role of the lung and generation of RA-related autoantibodies in a period of disease development termed "preclinical RA." Finally, we will discuss the role of ACPA and other Abs in non-RA pulmonary diseases and discuss a research agenda for next steps in the understanding and management of the lung in RA.
虽然类风湿关节炎（RA）的主要表现是关节疾病，但也可能出现关节外疾病。特别是肺部疾病是血清阳性RA常见的关节外表现，也是该人群发病和死亡的主要原因。本综述将重点介绍过去几年发表的研究，尤其会讨论抗瓜氨酸化蛋白/肽抗原（ACPA）抗体与RA患者肺部疾病之间的关系。我们还将回顾有关在疾病发展的“临床前期RA”阶段肺的潜在作用以及RA相关自身抗体产生的数据。最后，我们将讨论ACPA和其他抗体在非RA肺部疾病中的作用，并讨论在理解和管理RA肺部疾病方面下一步的研究议程。
