Wang Qiu-xu, Wang Tian-xiang, Liu Wei-xian
Department of Oral and Maxillofacial Surgery, Shengjing Hospital of China Medical University. Shenyang 110004, Liaoning Province, China.
Shanghai Kou Qiang Yi Xue. 2011 Jun;20(3):269-72.
To reveal the relations between expression of extracellular signal-regulated kinase (ERK) and nm23-H1 and tumor invasion and metastasis in tongue squamous cell carcinoma (TSCC).
The expression of ERK and nm23-H1 at protein level was examined in 74 cases of TSCC by strep avidin-biotin complex (SABC) immunohistochemical technique. SPSS10.0 software package was used for data analysis.
The expression of ERK was positively related to TNM clinical stage and cervical lymph node metastasis. The expression of nm23-H1 was negatively related to TNM clinical stage and cervical lymph node metastasis. The expression of ERK had a negative correlation with the expression of nm23-H1. TSCC cases with ERK(+)/nm23-H1(-) revealed significant higher tendency to cervical lymph node metastasis than those with ERK(-)/nm23-H1(+).
The expression of ERK and nm23-H1 is correlated with invasion and cervical lymph node metastasis in TSCC.
