Department of Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8521, USA.
Diabetologia. 2011 Oct;54(10):2515-24. doi: 10.1007/s00125-011-2252-z. Epub 2011 Jul 22.
AIMS/HYPOTHESIS: Plasma levels of adiponectin are inversely associated with body mass. We hypothesised that adipose tissue distribution and body composition influences adiponectin levels.
We assessed plasma adiponectin concentrations and dual-energy X-ray absorptiometry (DEXA) measurements of body composition among 2,820 participants from the Dallas Heart Study.
Among both women and men, adiponectin levels were higher in whites than in either Hispanics or African-Americans (for women: median 9.99 μg/ml [25th,75th percentile 7.11, 13.77] vs 7.56 μg/ml [5.05, 9.98] vs 6.39 μg/ml [4.37, 9.41], respectively, p < 0.0001; for men: 6.43 μg/ml [4.66, 9.19] vs 5.55 μg/ml [3.64, 7.50] vs 5.03 μg/ml [3.39, 7.28], p < 0.0001). In univariate analysis, each individual component of body mass was inversely associated with adiponectin. After multivariate analysis, adiponectin levels were found to be positively associated with lower extremity fat, whether expressed in absolute mass (for women: β = 0.055, p < 0.0001; for men: β = 0.061, p < 0.0001), or as a relative proportion (for women: β = 0.035, p < 0.0001; for men: β = 0.034, p < 0.0001). This association was consistent across ethnicities. Conversely, adiponectin was negatively correlated with truncal fat, both in absolute (for women: β = -0.039, p < 0.0001; for men: β = -0.044, p < 0.0001) and relative terms (for women: β = -0.027, p < 0.0001; for men β = -0.033, p < 0.0001). At the extreme of body mass, higher degrees of lower extremity and truncal adiposity were associated with higher levels of adiponectin.
CONCLUSIONS/INTERPRETATION: These data suggest that the location of adipose depots differentially influences circulating adiponectin concentrations-a finding observed across ethnicity and sex. Gross measures of body mass alone do not adequately account for adiponectin levels. This supports a role of adiponectin as a mediator of the positive effects of lower extremity adiposity on improvements in insulin sensitivity.
目的/假设：血浆脂联素水平与体重呈负相关。我们假设脂肪组织分布和身体成分会影响脂联素水平。
我们评估了达拉斯心脏研究中 2820 名参与者的血浆脂联素浓度和双能 X 射线吸收法（DEXA）测量的身体成分。
在女性和男性中，白种人的脂联素水平均高于西班牙裔或非裔美国人（女性：中位数 9.99μg/ml[25 百分位，75 百分位 7.11，13.77]vs7.56μg/ml[5.05，9.98]vs6.39μg/ml[4.37，9.41]，p<0.0001；男性：6.43μg/ml[4.66，9.19]vs5.55μg/ml[3.64，7.50]vs5.03μg/ml[3.39，7.28]，p<0.0001）。在单变量分析中，体重的每个组成部分都与脂联素呈负相关。在多变量分析后，发现脂联素水平与下肢脂肪呈正相关，无论是以绝对质量（女性：β=0.055，p<0.0001；男性：β=0.061，p<0.0001）还是相对比例（女性：β=0.035，p<0.0001；男性：β=0.034，p<0.0001）表示。这种关联在不同种族中是一致的。相反，脂联素与躯干脂肪呈负相关，无论是以绝对（女性：β=-0.039，p<0.0001；男性：β=-0.044，p<0.0001）还是相对（女性：β=-0.027，p<0.0001；男性β=-0.033，p<0.0001）术语表示。在体重的极端情况下，下肢和躯干脂肪的增加与较高的脂联素水平相关。
结论/解释：这些数据表明，脂肪储存的位置会对循环脂联素浓度产生不同的影响——这一发现在不同种族和性别中均观察到。体重的总体指标并不能充分解释脂联素水平。这支持了脂联素作为下肢脂肪丰度对胰岛素敏感性改善的积极影响的中介的作用。
