转录因子结合位点的计算机模拟预测
In silico prediction of transcriptional factor-binding sites.
作者信息
Oshchepkov Dmitry Y, Levitsky Victor G
机构信息
Laboratory of Theoretical Genetics, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
出版信息
Methods Mol Biol. 2011;760:251-67. doi: 10.1007/978-1-61779-176-5_16.
The recognition of transcription factor binding sites (TFBSs) is the first step on the way to deciphering the DNA regulatory code. A large variety of computational approaches and corresponding in silico tools for TFBS recognition are available, each having their own advantages and shortcomings. This chapter provides a brief tutorial to assist end users in the application of these tools for functional characterization of genes.
转录因子结合位点（TFBSs）的识别是解读DNA调控密码过程中的第一步。目前有各种各样用于TFBS识别的计算方法和相应的计算机模拟工具，每种方法和工具都有其自身的优缺点。本章提供一个简要教程，以帮助终端用户应用这些工具对基因进行功能表征。
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