Department of Surgical Oncology and Digestive Surgery, Kagoshima University Graduate School, Kagoshima, Japan.
J Surg Oncol. 2012 Feb;105(2):195-9. doi: 10.1002/jso.22024. Epub 2011 Jul 20.
Mesothelin expression is found in normal mesothelium, and cancerous mesothelin has been recently reported in ovarian and pancreas cancer. The clinicopathological implications of mesothelin expression have been discussed with respect to antitumor immunological mechanisms. However, there is no information on mesothelin expression in gastric cancer. The purpose of the current study is to identify the clinical significance of mesothelin in gastric cancer.
A total of 212 gastric cancer patients who received R0 gastrectomy at Kagoshima University Hospital were enrolled in this study. Mesothelin was detected immunohistochemically and visualized by ABC method. Intensity of cancerous mesothelin was divided into two categories (0-50%: negative group and 51-100%: positive group).
Mesothelin expression was detected in the cellular membrane. In accordance with the previous evaluation, patients were divided into two groups [mesothelin-positive group: 124 (59%) and mesothelin-negative group: 88 (41%)]. The mesothelin-positive group had significantly more nodal involvement and significantly deeper tumor invasion than the mesothelin-negative group (P < 0.05). However, by analysis confined to the 117 advanced gastric cancer patients, the 5-year survival rate of the mesothelin-positive group was 55%, which was significantly better than that of the mesothelin-negative group. Multivariate analysis revealed that mesothelin expression is one of the independent prognostic factors of gastric cancer.
Cancerous mesothelin expression in gastric cancer may be a useful tool to predict patient survival.
间皮素在正常间皮细胞中表达，最近有报道称卵巢癌和胰腺癌中存在癌性间皮素。已经讨论了间皮素表达与抗肿瘤免疫机制的临床病理相关性。然而，关于胃癌中间皮素的表达尚无信息。本研究的目的是确定间皮素在胃癌中的临床意义。
共纳入在鹿儿岛大学医院接受 R0 胃切除术的 212 例胃癌患者进行本研究。采用 ABC 法免疫组织化学法检测间皮素并进行可视化。将癌性间皮素的强度分为两类（0-50%：阴性组和 51-100%：阳性组）。
在细胞膜上检测到间皮素表达。根据之前的评估，患者被分为两组[间皮素阳性组：124 例（59%）和间皮素阴性组：88 例（41%）]。间皮素阳性组的淋巴结受累和肿瘤浸润深度明显高于间皮素阴性组（P<0.05）。然而，对 117 例进展期胃癌患者进行分析后发现，间皮素阳性组的 5 年生存率为 55%，明显优于间皮素阴性组。多因素分析显示，间皮素表达是胃癌的独立预后因素之一。
胃癌中的癌性间皮素表达可能是预测患者生存的有用工具。
