Department of Animal Morphology and Physiology, Federal Rural University of Pernambuco, Recife, Pernambuco, Brazil.
J Appl Toxicol. 2013 Jan;33(1):24-31. doi: 10.1002/jat.1702. Epub 2011 Jul 21.
Olanzapine is an atypical antipsychotic drug that has been increasingly used in acute treatment of, and therapeutic support for, schizophrenia, bipolar disorder and other psychoses. Considering that olanzapine acts on the dopaminergic receptor and this receptor is detected in germ cells, the present study aims to investigate the effects of treatment with different doses of olanzapine on spermatogenesis, plasma testosterone and weight of androgen-dependent organs in rats. Results showed reduced plasma testosterone levels, and reduced testis, epididymis and prostate weights. Histopathologic and histomorphometric analysis of spermatogenesis indicated testicular degeneration. Furthermore, germ cell desquamation, syncytial multinucleated cells, Sertoli cell vacuolization and presence of necrotic and apoptotic germ cells wwew observed. Olanzapine treatment in rats promoted endocrinological changes and lesions in the testis, leading to a disturbance in spermatogenesis.
奥氮平是一种非典型抗精神病药物，已越来越多地用于精神分裂症、双相情感障碍和其他精神病的急性治疗和治疗支持。考虑到奥氮平作用于多巴胺能受体，而这种受体存在于生殖细胞中，本研究旨在探讨不同剂量奥氮平治疗对大鼠生殖功能、血浆睾酮和雄激素依赖器官重量的影响。结果显示，血浆睾酮水平降低，睾丸、附睾和前列腺重量减轻。生精功能的组织病理学和组织形态计量学分析表明睾丸退化。此外，还观察到精母细胞脱落、合胞多核细胞、支持细胞空泡化以及坏死和凋亡的生殖细胞。奥氮平治疗大鼠可促进睾丸的内分泌变化和损伤，导致生精功能障碍。
