陆地绵霉素 A 的全合成，一种强效的抗肿瘤蒽环类抗生素。
Total synthesis of landomycin A, a potent antitumor angucycline antibiotic.
机构信息
State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
出版信息
J Am Chem Soc. 2011 Aug 17;133(32):12433-5. doi: 10.1021/ja205339p. Epub 2011 Jul 27.
PMID:21780843
Abstract
The first total synthesis of landomycin A, the longest and most potent antitumor angucycline antibiotic, has been achieved in 63 steps and 0.34% overall yield starting from 2,5-dihydroxybenzoic acid, 3,5-dimethylphenol, triacetyl d-glucal, and d-xylose, with a convergent linear sequence of 21 steps.
摘要
土霉素 A 的全合成，最长和最强的抗肿瘤蒽环类抗生素，已经实现了在 63 步和 0.34%的总产率从 2,5-二羟基苯甲酸，3,5-二甲苯酚，三乙酰基 d-葡萄糖醛酸，和 d-木糖，具有收敛线性序列 21 步。
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