King Abdul Aziz University Hospital, Jeddah, Saudi Arabia.
Expert Rev Gastroenterol Hepatol. 2011 Aug;5(4):517-22. doi: 10.1586/egh.11.45.
Autoimmune hepatitis (AIH) is a chronic liver disease of unknown etiology that is responsive to steroid and azathioprine treatment in more than 80% of patients after 3 years of treatment. There are few alternative treatment options for individuals with AIH who are unresponsive to steroids and azathioprine, and research on this is limited to open-label studies of a variety of immunosuppressive agents that involve only small numbers of patients. Mycophenolate mofetil is one of the most frequently used alternative agents for the treatment of AIH patients not responsive to standard therapy. In this article, we review and summarize currently available data regarding the use of mycophenolate mofetil as an alternative treatment option for patients with AIH.
自身免疫性肝炎（AIH）是一种病因不明的慢性肝脏疾病，在接受治疗 3 年后，超过 80%的患者对类固醇和硫唑嘌呤治疗有反应。对于那些对类固醇和硫唑嘌呤无反应的 AIH 患者，几乎没有其他替代治疗选择，而且对此类患者的研究仅限于涉及少数患者的各种免疫抑制剂的开放标签研究。霉酚酸酯是治疗对标准治疗无反应的 AIH 患者最常用的替代药物之一。本文综述并总结了目前关于霉酚酸酯作为 AIH 患者替代治疗选择的应用数据。
