Department of Liver and Biliopancreatic disorders, University Hospital Gasthuisberg, KU Leuven, Leuven, Belgium.
Expert Rev Gastroenterol Hepatol. 2011 Aug;5(4):523-37; quiz 537. doi: 10.1586/egh.11.47.
In recent years, acute-on-chronic liver failure has been recognized as a specific clinical form of liver failure associated with cirrhosis. The syndrome refers to an acute deterioration of liver function and subsequently of other end organs over a period of weeks following a precipitating event in a patient with previously well- or reasonably well-compensated cirrhosis. These precipitating events include either an indirect (e.g., variceal hemorrhage, sepsis) or a direct (e.g., drug-induced) hepatotoxic factor. The short-term mortality for this condition is more than 50%. At present, considerable efforts are ongoing to better characterize the syndrome, to gain further insight into its pathophysiology and to optimize therapy. This article aims to highlight the current concepts of these various aspects.
近年来，慢加急性肝衰竭已被认为是一种与肝硬化相关的特定临床类型的肝衰竭。该综合征是指在代偿良好或基本代偿的肝硬化患者，在经历一次诱发事件后数周内，肝功能和其他终末器官发生急性恶化。这些诱发事件包括间接（如食管胃静脉曲张出血、败血症）或直接（如药物性肝损伤）肝毒性因素。这种情况下的短期死亡率超过 50%。目前，人们正在努力更好地描述该综合征，深入了解其病理生理学，并优化治疗。本文旨在强调这些方面的当前概念。
