Oral Maxillofacial Unit, New Mulago Hospital, Kampala, Uganda.
Acta Odontol Scand. 2012 Mar;70(2):149-53. doi: 10.3109/00016357.2011.600709. Epub 2011 Jul 25.
Certain oral manifestations signal progression of HIV disease among HAART naïve patients or an increase in the plasma HIV-1 RNA levels for those on treatment. Ranulas may be one of those manifestations. Therefore, this study describes the clinical features of patients who presented with ranulas including their demographics, HIV sero-status and the CD4 CD8 cell counts for those who were HIV positive.
A prospective study on ranulas was undertaken at Mulago national referral hospital and St Mary's hospital Lacor covering the period December 2008 to November 2009.
Fifty-seven cases participated in the study: 38.6% male and 61.4% female. Out of the study group, 73.7% were HIV positive. This was statistically significant (Chi = 12.789, df = 1, p = 0.001). In relation, to CD4 cell count, 23.8% had <200 cells/mm(3), 35.7% between 200-500 cells/mm(3) and 40.5% more than 500 cells/mm(3). The CD4-to-CD8 ratio ranged from 0.02-0.98 with an average of 0.31 ± 0.23, median and mode of 0.27 and 0.32, respectively.
It is felt that ranulas may be one of the oral manifestations of worsening immunity in HIV/AIDS disease. Therefore, more research is needed to establish if it should be included among known oral manifestations of the disease.
某些口腔表现可能预示着未经抗逆转录病毒治疗（HAART）的 HIV 疾病进展或治疗患者血浆 HIV-1 RNA 水平升高。舌下囊肿可能是其中之一。因此，本研究描述了出现舌下囊肿的患者的临床特征，包括他们的人口统计学特征、HIV 血清状态以及 HIV 阳性患者的 CD4+CD8+细胞计数。
在 2008 年 12 月至 2009 年 11 月期间，在马拉戈国家转诊医院和圣玛丽医院 Lacor 进行了一项关于舌下囊肿的前瞻性研究。
57 例患者参与了这项研究：38.6%为男性，61.4%为女性。研究组中，73.7%为 HIV 阳性。这具有统计学意义（Chi = 12.789，df = 1，p = 0.001）。关于 CD4 细胞计数，23.8%的患者<200 个细胞/mm3，35.7%的患者在 200-500 个细胞/mm3 之间，40.5%的患者>500 个细胞/mm3。CD4/CD8 比值范围为 0.02-0.98，平均为 0.31±0.23，中位数和模式分别为 0.27 和 0.32。
舌下囊肿可能是 HIV/AIDS 疾病免疫功能恶化的口腔表现之一。因此，需要进一步研究以确定其是否应包括在该疾病已知的口腔表现中。
