Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan.
Free Radic Res. 2011 Oct;45(10):1223-31. doi: 10.3109/10715762.2011.607252. Epub 2011 Aug 18.
Curcumin is used anecdotally as an herb in traditional Indian and Chinese medicine. In the present study, the effects and possible mechanism of curcumin in experimental autoimmune myocarditis (EAM) rats were further investigated. They were divided randomly into a treatment and vehicle group, and orally administrated curcumin (50 mg/kg/day) and 1% gum arabic, respectively, for 3 weeks after myosin injection. The results showed that curcumin significantly suppressed the myocardial protein expression of inducible nitric oxide synthase (iNOS) and the catalytic subunit of nicotinamide adenine dinucleotide phosphate reduced (NADPH) oxidase. In addition, curcumin significantly decreased myocardial endoplasmic reticulum (ER) stress signaling proteins and improved cardiac function. Furthermore, curcumin significantly decreased the key regulators or inducers of apoptosis. In summary, our results indicate that curcumin has the potential to protect EAM by modulating cardiac oxidative and ER stress-mediated apoptosis, and provides a novel therapeutic strategy for autoimmune myocarditis.
姜黄素在传统的印度和中医中被用作草药。在本研究中，进一步研究了姜黄素在实验性自身免疫性心肌炎（EAM）大鼠中的作用和可能的机制。它们被随机分为治疗组和载体组，并在肌球蛋白注射后分别口服姜黄素（50mg/kg/天）和 1%阿拉伯胶，持续 3 周。结果表明，姜黄素显著抑制诱导型一氧化氮合酶（iNOS）和烟酰胺腺嘌呤二核苷酸磷酸还原酶（NADPH）氧化酶的催化亚基在心肌中的蛋白表达。此外，姜黄素还显著降低了心肌内质网（ER）应激信号蛋白，改善了心脏功能。此外，姜黄素还显著降低了凋亡的关键调节因子或诱导因子。总之，我们的结果表明，姜黄素通过调节心脏氧化应激和 ER 应激介导的细胞凋亡来保护 EAM，为自身免疫性心肌炎提供了一种新的治疗策略。
