Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Clin Endocrinol (Oxf). 2012 Apr;76(4):520-5. doi: 10.1111/j.1365-2265.2011.04182.x.
Leptin is anorexigenic, and levels are markedly decreased in women with low body weight and high in women with obesity. Ghrelin opposes leptin effects on appetite and is negatively associated with body mass index. These appetite-regulating hormones may have opposing effects on mood and stress pathways. Women with anorexia nervosa (AN), hypothalamic amenorrhoea (HA) and obesity are at increased risk of depression and anxiety. It is unknown whether dysregulation of leptin or ghrelin contributes to the development of depression and/or anxiety in these disorders. We investigated the relationship between leptin and ghrelin levels and symptoms of depression, anxiety and perceived stress in women across the weight spectrum.
Cross-sectional.
64 women: 15 with AN, 12 normal-weight with HA, 17 overweight or obese (OB) and 20 normal-weight in good health (HC).
Fasting serum leptin and plasma ghrelin levels were measured. Hamilton Rating Scales for Depression (HAM-D) and Anxiety (HAM-A) and the Perceived Stress Scale were administered.
Leptin levels were inversely associated with HAM-D, HAM-A and Perceived Stress scores. The negative relationships between leptin and severity of symptoms of both depression and anxiety remained significant after controlling for body fat or weight. There was no relationship between ghrelin and symptoms of depression or anxiety. Although ghrelin levels were positively associated with the degree of perceived stress, this relationship was not significant after controlling for body fat or weight.
Leptin may mediate depressive symptoms across the weight spectrum. Further investigation of the role of leptin in modulating mood will be important.
瘦素具有抑制食欲的作用，体重低和肥胖的女性瘦素水平明显降低。Ghrelin 与瘦素对食欲的作用相反，与体重指数呈负相关。这些调节食欲的激素可能对情绪和应激途径有相反的影响。神经性厌食症（AN）、下丘脑性闭经（HA）和肥胖的女性患抑郁和焦虑的风险增加。瘦素或 Ghrelin 是否失调导致这些疾病中抑郁和/或焦虑的发展尚不清楚。我们研究了瘦素和 Ghrelin 水平与抑郁、焦虑和感知压力症状在整个体重范围内的女性之间的关系。
横断面研究。
64 名女性：15 名 AN 患者，12 名正常体重伴 HA，17 名超重或肥胖（OB），20 名正常体重健康（HC）。
空腹血清瘦素和血浆 Ghrelin 水平。进行汉密尔顿抑郁量表（HAM-D）和焦虑量表（HAM-A）和感知压力量表评估。
瘦素水平与 HAM-D、HAM-A 和感知压力评分呈负相关。在控制体脂或体重后，瘦素与抑郁和焦虑严重程度之间的负相关关系仍然显著。Ghrelin 与抑郁或焦虑症状之间没有关系。虽然 Ghrelin 水平与感知压力的程度呈正相关，但在控制体脂或体重后，这种关系并不显著。
瘦素可能在整个体重范围内介导抑郁症状。进一步研究瘦素在调节情绪中的作用将是重要的。
