Camacho-Arroyo Ignacio, Flores-Ramos Mónica, Mancilla-Herrera Ismael, Cruz-Coronel Fausto Manuel, Farfan-Labonne Blanca, Jiménez-Aquino Laura Elena, Meza-Rodríguez María Del Pilar, Hernández-Ruiz Joselin, Leff-Gelman Philippe
Unidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología-Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de Mexico 04510, Mexico.
Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de Mexico 14370, Mexico.
J Clin Med. 2025 Jun 10;14(12):4102. doi: 10.3390/jcm14124102.
Adipokines secreted by the adipose tissue and placenta play a critical role in regulating metabolic functions that are essential for fetoplacental development and embryonic growth. While adipokines are known to impact a wide range of physiological and pathological conditions, their role in affective disorders during pregnancy remains underexplored. In this study, we aimed to assess the serum levels of distinct adipokines and examine their association with anxiety and comorbid depression in pregnant women. Third-trimester pregnant women with severe anxiety (ANX, = 45) and anxiety plus depressive symptoms (ANX + DEP, = 61) were enrolled in the study, along with healthy control subjects (CTRL, = 33). Participants were classified using the Hamilton Anxiety Rating Scale (HARS) and the Hamilton Depression Rating Scale (HDRS). Serum levels of adiponectin, adipsin, leptin, and resistin were quantified by flow cytometry-based immunoassay. Clinical, biochemical, and demographic parameters were analyzed using ANOVA with a post hoc Tukey test. Pearson bivariate and partial correlations were performed to assess associations between variables. Adipokine serum levels were significantly higher in the symptomatic groups (ANX, ANX + DEP) than in the CTRL group ( < 0.001). Adiponectin, leptin, and resistin levels positively correlated with anxiety symptoms (HARS, < 0.01). Furthermore, resistin levels showed a strong association with depressive symptoms (HDRS, = 0.001) in the ANX + DEP group, after adjusting all parameters by clinical confounders. Our findings revealed that both pro- and anti-inflammatory adipokine levels are elevated in women with affective symptoms during late pregnancy. Pro-inflammatory properties of leptin and resistin may contribute to the severity of anxiety symptoms. Notably, resistin emerges as a key adipokine associated with the expression of depressive symptoms. In addition, adiponectin, acting as an anti-inflammatory mediator, may counteract the inflammatory responses induced by leptin and resistin. These results provide new insights into the role of specific adipocytokine in women with affective disorders during late pregnancy.
脂肪组织和胎盘分泌的脂肪因子在调节对胎儿胎盘发育和胚胎生长至关重要的代谢功能中起着关键作用。虽然已知脂肪因子会影响广泛的生理和病理状况，但其在孕期情感障碍中的作用仍未得到充分研究。在本研究中，我们旨在评估不同脂肪因子的血清水平，并研究它们与孕妇焦虑及共病抑郁的关联。研究纳入了患有严重焦虑（ANX，n = 45）和焦虑加抑郁症状（ANX + DEP，n = 61）的孕晚期妇女，以及健康对照受试者（CTRL，n = 33）。使用汉密尔顿焦虑量表（HARS）和汉密尔顿抑郁量表（HDRS）对参与者进行分类。通过基于流式细胞术的免疫测定法定量血清脂联素、脂肪酶、瘦素和抵抗素水平。使用方差分析及事后Tukey检验分析临床、生化和人口统计学参数。进行Pearson双变量和偏相关分析以评估变量之间的关联。有症状组（ANX、ANX + DEP）的脂肪因子血清水平显著高于CTRL组（P < 0.001）。脂联素、瘦素和抵抗素水平与焦虑症状（HARS，P < 0.01）呈正相关。此外，在通过临床混杂因素调整所有参数后，抵抗素水平在ANX + DEP组中与抑郁症状（HDRS，P = 0.001）显示出强烈关联。我们的研究结果表明，孕晚期有情感症状的女性中促炎和抗炎脂肪因子水平均升高。瘦素和抵抗素的促炎特性可能导致焦虑症状的严重程度。值得注意的是，抵抗素是与抑郁症状表达相关的关键脂肪因子。此外，作为抗炎介质的脂联素可能会抵消由瘦素和抵抗素诱导的炎症反应。这些结果为特定脂肪细胞因子在孕晚期患有情感障碍的女性中的作用提供了新的见解。
