Budan B, Ekici B, Tatli B, Somer A
Department of Paediatric Infectious Disease, Faculty of Medicine, University of Istanbul, Turkey.
Ann Trop Paediatr. 2011;31(3):269-72. doi: 10.1179/1465328111Y.0000000028.
Acute disseminated encephalomyelitis (ADEM) is an immune-mediated demyelinating disorder of the central nervous system which is usually precipitated by a viral infection or vaccination. A 3-month-old boy is reported who developed ADEM a week after full recovery from pertussis. MRI detected a high-intensity lesion extending from the pons to the mesencephalon, compatible with ADEM. Following the administration of intravenous immunoglobulins, the patient's clinical symptoms improved. This case report demonstrates that pertussis is capable of inducing an immune-mediated demyelinating disorder of the central nervous system.
急性播散性脑脊髓炎（ADEM）是一种中枢神经系统的免疫介导性脱髓鞘疾病，通常由病毒感染或疫苗接种引发。据报道，一名3个月大的男孩在百日咳完全康复一周后患上了ADEM。磁共振成像（MRI）检测到一个从脑桥延伸至中脑的高强度病变，符合ADEM表现。静脉注射免疫球蛋白后，患者的临床症状有所改善。本病例报告表明，百日咳能够诱发中枢神经系统的免疫介导性脱髓鞘疾病。
