Shi Zhen, Liao Jia-Zhi, Cheng Bin, Hu Dao-Yu, Tong Yi-Xin, Wan Jie
Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhonghua Nei Ke Za Zhi. 2011 Jun;50(6):485-8. doi: 10.3760/cma.j.issn.0578-1426.2011.06.010.
To study the pathological and immunohistochemical features of alimentary tract mesenchymal tumors and compare with computed tomographic virtue endoscopy (CTVE) imaging technology to evaluate the diagnostic value of CTVE in alimentary tract mesenchymal tumors.
Seventy-four pathological specimens of alimentary tract mesenchymal tumors were collected. The pathological features and the expression of CD(117), CD(34), SMA and S-100 were observed by immunohistochemical method with light microscope. The pathological types and characteristics were determined by pathologists and compared with CTVE imaging technology.
In the 74 cases of alimentary tract mesenchymal tumors, 40 cases were diagnosed as stromal tumor with pathological and immunohistochemical methods(54.1%). Sixteen of them were malignant, accounting for 40% of the stromal tumor while 33 cases were diagnosed as leiomyoma (44.6%) and 1 case as schwannoma (1.4%). In the 74 GIMTs cases, 33 were jejunum GIMTs, 21 were ileum GIMTs and 20 were large intestine GIMTs. Immunohistochemistry assay in the 74 GIMTs cases showed that 51.4% GIMTs were positive for CD(117), approximately 36.5% were positive for CD(34), 62.2% were positive for smooth-muscle actin (SMA) and 1.4% were positive for S-100 protein. In the 74 GIMTs cases, 69 cases were diagnosed right in the accuracy for location with CTVE (93.2%) with 51 cases in small intestinal (94.4%) and 18 cases in large intestinal (90.0%). The sensitivity and the specificity of CTVE to distinguish benign from malignant stromal tumors by CTVE characteristics were 84.2% and 85.7% respectively.
GIST is common in GIMTs and is often originated from the small intestinal. The immunohistochemistry has great value in diagnosing alimentary tract mesenchymal tumors. The CTVE imaging technology also has great value in diagnosing alimentary tract mesenchymal tumors which can show the localization, shape size and artery of the tumor clearly. The diagnostic sensitivity and specificity of CTVE are high to distinguish benign from malignant alimentary tract GISTs. CTVE plays an important role in guiding the clinical management of GISTs.
研究消化道间叶组织肿瘤的病理及免疫组化特征，并与螺旋CT仿真内镜（CTVE）成像技术比较，探讨CTVE对消化道间叶组织肿瘤的诊断价值。
收集74例消化道间叶组织肿瘤的病理标本，采用免疫组化方法，光镜下观察其病理特征及CD117、CD34、平滑肌肌动蛋白（SMA）、S-100的表达情况。由病理科医师确定病理类型及特征，并与CTVE成像技术进行对照分析。
74例消化道间叶组织肿瘤中，病理及免疫组化确诊为间质瘤40例（54.1%），其中恶性间质瘤16例，占间质瘤的40%；平滑肌瘤33例（44.6%），神经鞘瘤1例（1.4%）。74例消化道间叶组织肿瘤中，空肠33例，回肠21例，大肠20例。74例消化道间叶组织肿瘤免疫组化结果显示：CD117阳性率51.4%，CD34阳性率约36.5%，平滑肌肌动蛋白（SMA）阳性率62.2%，S-100蛋白阳性率1.4%。74例消化道间叶组织肿瘤中，CTVE定位诊断准确69例（93.2%），其中小肠51例（94.4%），大肠18例（90.0%）。CTVE根据特征区分良恶性间质瘤的敏感度和特异度分别为84.2%和85.7%。
消化道间叶组织肿瘤以胃肠道间质瘤（GIST）多见，多起源于小肠。免疫组化对消化道间叶组织肿瘤的诊断有重要价值。CTVE成像技术对消化道间叶组织肿瘤的诊断也有重要价值，能清晰显示肿瘤的部位、形态、大小及血供情况。CTVE对消化道GIST良恶性的诊断敏感度和特异度较高，对指导GIST的临床处理有重要作用。
Zotero 插件