Huang Xiu, He Min, Liu Ying-jiang, Zhang Lian, Wang Zhi-biao
College of Biomedical Engineering, Chongqing Medical University, China.
Zhonghua Fu Chan Ke Za Zhi. 2011 Jun;46(6):412-5.
To explore the effect of oxytocin on uterine fibroids treated by ultrasound ablation.
Eighty-two single points in 29 uterine fibroids from 26 patients were sonicated with magnetic resonance imaging guided by high intensity focused ultrasound before and after using oxytocin. The required total energy, sonication time required to reach 60°C and the acoustic energy for increasing 1°C of temperature at the single point before and after using oxytocin were compared.
Before intravenous infusion of oxytocin, the average total sonication energy required to reach 60°C was (5320 ± 910) J and it took (21 ± 20) seconds for sonicating a single point, the energy required for increasing 1°C was (255 ± 302) J. In contrast, after intravenous infusion of oxytocin, the average total sonication energy required to reach 60°C was (2890 ± 325) J, and it took (12 ± 7) seconds for sonicating a single point, the energy required for increasing 1°C was (126 ± 94) J. Those three index all reached statistical difference (P = 0.002, P = 0.001, P = 0.002, respectively).
It seemed that Oxytocin could significantly decrease the energy required for ablating uterine fibroids, shorten treatment time and improve the treatment efficiency.
探讨缩宫素对超声消融治疗子宫肌瘤的影响。
对26例患者的29个子宫肌瘤中的82个单点，在使用缩宫素前后，采用磁共振成像引导下的高强度聚焦超声进行超声处理。比较使用缩宫素前后达到60°C所需的总能量、达到60°C所需的单点超声处理时间以及单点温度升高1°C所需的声能。
静脉输注缩宫素前，达到60°C所需的平均总超声能量为(5320±910)J)，单点超声处理时间为(21±20)秒，温度升高1°C所需能量为(255±302)J。相比之下，静脉输注缩宫素后，达到60°C所需的平均总超声能量为(2890±325)J，单点超声处理时间为(12±7)秒，温度升高1°C所需能量为(126±94)J。这三个指标均达到统计学差异（分别为P=0.002、P=0.001、P=0.002）。
缩宫素似乎可以显著降低消融子宫肌瘤所需的能量，缩短治疗时间并提高治疗效率。
