[高密度脂蛋白胆固醇的酯化分数率与冠状动脉疾病之间的关系]

[Relationship between fractional esterification rate of high density lipoprotein cholesterol and coronary artery disease].

作者信息

Mao Wen, Dong Jun, Li Hong-xia, Zhou Min, Guo Han-bang, Wang Shu, Chen Wen-xiang, He Qing

机构信息

Department of Cardiology, Beijing Hospital, Beijing 100730, China.

出版信息

Zhonghua Xin Xue Guan Bing Za Zhi. 2011 May;39(5):402-5.

PMID:21781592

Abstract

OBJECTIVE

To assess the relationship between fractional esterification rate of high density lipoprotein cholesterol (FER(HDL)) and coronary artery disease.

METHODS

A total of 131 hospitalized patients underwent coronary angiography due to chest pain were included in the study and patients were divided into CAD group (n = 76) and non CAD group (n = 55) according to coronary angiogram. Clinical and laboratory data including biochemical laboratory, FER(HDL) and lipid subclasses were analyzed.

RESULTS

The FER(HDL) value of CAD group was significantly higher than that of the non CAD group (21.70 ± 8.73 vs. 18.65 ± 6.26, P < 0.05). There was an increased trend of FER(HDL) with numbers of diseased coronary arteries, significant difference was evidenced between non CAD group and 3-vessel group (18.65 ± 6.26 vs. 24.00 ± 9.22, P < 0.05). FER(HDL) was positively correlated with TG (r = 0.647, P < 0.001), LDLb-C(r = 0.441, P < 0.001) and negatively correlated with HDL-C (r = -0.708, P < 0.001) and HDL(2)-C (r = -0.748, P < 0.001).

CONCLUSION

Our data showed that the values of FER(HDL) were significantly increased in CAD patients and correlated with the severity of the CAD.

摘要

目的

评估高密度脂蛋白胆固醇的酯化率（FER(HDL)）与冠状动脉疾病之间的关系。

方法

本研究纳入了131例因胸痛住院并接受冠状动脉造影的患者，根据冠状动脉造影结果将患者分为冠心病组（n = 76）和非冠心病组（n = 55）。分析临床和实验室数据，包括生化指标、FER(HDL)和脂质亚类。

结果

冠心病组的FER(HDL)值显著高于非冠心病组（21.70±8.73 vs. 18.65±6.26，P < 0.05）。FER(HDL)随病变冠状动脉数量增加呈上升趋势，非冠心病组与三支血管病变组之间存在显著差异（18.65±6.26 vs. 24.00±9.22，P < 0.05）。FER(HDL)与甘油三酯（r = 0.647，P < 0.001）、低密度脂蛋白b - C（r = 0.441，P < 0.001）呈正相关，与高密度脂蛋白胆固醇（r = -0.708，P < 0.001）和高密度脂蛋白(2)-C（r = -0.748，P < 0.001）呈负相关。