Xue Chao, Sun Yi-hong, Ding Rong-jing, Fu Yuan-yuan, Hu Da-yi
Department of Cardiology, People's Hospital of Peking University, Beijing 100044, China.
Zhonghua Xin Xue Guan Bing Za Zhi. 2011 May;39(5):410-3.
To explore the effect of acute smoking on vascular endothelial function, arterial stiffness and the possible underlying mechanisms.
We measured the endothelial function and arterial stiffness in 50 healthy chronic smokers before and after acute smoking with EndoPAT2000. The test was carried out on two separate finger tips. The endothelial function was evaluated by PAT ratio of the finger tip and systemic arterial stiffness was evaluated by augmentation index (AI). Plasma soluble intercellular adhesion molecule-1 (sICAM-1) and tissue plasminogen activator (tPA) before and 20 min after acute smoking were measured with enzyme linked immuno sorbent assay.
The PAT ratio was decreased (1.87 ± 0.40 vs. 1.73 ± 0.28, P = 0.004) while AI was significantly increased after acute smoking (2.94% ± 21.77% vs. 7.11% ± 20.65%, P = 0.01). There was no significant changes in sICAM [(306.5 ± 76.1) µg/L vs. (315.7 ± 90.9) µg/L, P = 0.402], but tPA [7.87 (5.41 - 10.08) µg/L vs. 5.77 (3.77 - 9.68) µg/L, P < 0.01] was significantly decreased after smoking.
Smoking could acutely affect endothelia function, arterial stiffness and deteriorate the activity of fibrinolytic system which could lead to coronary thrombosis in smokers.
探讨急性吸烟对血管内皮功能、动脉僵硬度及潜在机制的影响。
我们使用EndoPAT2000对50名健康慢性吸烟者在急性吸烟前后的内皮功能和动脉僵硬度进行了测量。测试在两个不同的指尖进行。通过指尖的脉搏波传导速度比值（PAT比值）评估内皮功能，通过增强指数（AI）评估全身动脉僵硬度。采用酶联免疫吸附测定法测量急性吸烟前及吸烟后20分钟血浆可溶性细胞间黏附分子-1（sICAM-1）和组织型纤溶酶原激活剂（tPA）水平。
急性吸烟后PAT比值降低（1.87±0.40对1.73±0.28，P = 0.004），而AI显著升高（2.94%±21.77%对7.11%±20.65%，P = 0.01）。sICAM水平无显著变化[（306.5±76.1）μg/L对（315.7±90.9）μg/L，P = 0.402]，但吸烟后tPA水平显著降低[7.87（5.41 - 10.08）μg/L对5.77（3.77 - 9.68）μg/L，P < 0.01]。
吸烟可急性影响内皮功能、动脉僵硬度，并使纤溶系统活性恶化，这可能导致吸烟者发生冠状动脉血栓形成。
