Department of Pharmacology and Environmental Toxicology, Dr. A.L.M. Postgraduate Institute of Basic Medical Sciences, University of Madras, Taramani, Madras 600 113, India.
Environ Toxicol Pharmacol. 1996 Apr 15;1(2):141-6. doi: 10.1016/1382-6689(95)00020-8.
The sedative and hypnotic effects of diazepam were tested in rats following chronic treatment with subconvulsive doses of the cyclodiene insecticides, endosulfan and aldrin. The anticonvulsant effect of diazepam was determined on picrotoxin-induced convulsions in insecticide-treated and control animals. Both endosulfan and aldrin promoted the convulsant action of picrotoxin indicating that the insecticides were able to show proconvulsant action following chronic administration. Interestingly, the protective effect of diazepam against picrotoxin-induced convulsions was greater in endosulfan- and aldrin-treated animals than in control animals. The sedative and hypnotic effects of diazepam were also increased in insecticide-treated animals. The mechanisms involved in the interaction were discussed with the support of the findings reported by the present and other investigators on the central and hepatic effects of chronic endosulfan and aldrin treatment.
慢性给予亚惊厥剂量的环二烯类杀虫剂，硫丹和艾氏剂后，在大鼠身上测试了地西泮的镇静和催眠作用。用士的宁诱发的惊厥来确定地西泮在杀虫剂处理过的和对照动物中的抗惊厥作用。硫丹和艾氏剂都促进了士的宁的惊厥作用，表明这些杀虫剂在长期给药后能够表现出促惊厥作用。有趣的是，地西泮对士的宁诱发的惊厥的保护作用在硫丹和艾氏剂处理的动物中比在对照动物中更大。地西泮的镇静和催眠作用也在杀虫剂处理的动物中增加。所涉及的相互作用的机制是通过本研究和其他研究人员关于慢性硫丹和艾氏剂处理的中枢和肝作用的发现来讨论的。
